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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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ICAM1 Antibody ICAM1/6319 / Cell Adhesion Molecule Antibody recognizes intercellular adhesion molecule 1 (ICAM1), a cell-surface glycoprotein and member of the immunoglobulin superfamily. Also known as ICAM-1 and CD54, the protein contains five extracellular immunoglobulin-like domains, a single transmembrane region, and a short cytoplasmic domain. ICAM1 functions as an important mediator of cell-cell adhesion and helps coordinate interactions between circulating immune cells, vascular endothelium, and other cell types.
ICAM1 is a major ligand for lymphocyte function-associated antigen 1 (LFA-1), an integrin composed of CD11a and CD18. It also interacts with the leukocyte integrin Mac-1, composed of CD11b and CD18. These interactions strengthen adhesion between leukocytes and other cells and contribute to leukocyte migration across vascular endothelium. ICAM1-mediated adhesion also helps stabilize contacts between lymphocytes and antigen-presenting cells during immune responses.
Expression of ICAM1 is highly responsive to inflammatory signals. Cytokines and other stimuli can substantially increase its expression on endothelial, epithelial, and immune cells, promoting leukocyte recruitment to sites of inflammation. This regulated expression has made ICAM1 an important target in studies of inflammation, immune cell trafficking, vascular biology, and tissue injury. Altered ICAM1 expression has also been investigated in cancer, where changes in cellular adhesion and the tumor microenvironment can influence disease progression.
ICAM1 additionally serves as a cellular receptor for major-group human rhinoviruses, connecting this adhesion molecule with mechanisms of viral attachment and infection. The protein is extensively N-glycosylated, which contributes to an apparent molecular weight substantially greater than that predicted from its amino acid sequence. Clone ICAM1/6319 is a mouse monoclonal antibody directed against human ICAM1 and provides a clone-specific reagent for investigating this multifunctional adhesion molecule.
NSJ Bioreagents offers this Cell Adhesion Molecule Antibody for research into ICAM1 expression and adhesion biology. An ICAM1 Antibody can support investigation of leukocyte trafficking, immune cell interactions, inflammatory responses, vascular biology, and other processes involving regulated cell adhesion.
Explore our CD Antibodies page for additional reagents targeting CD molecules involved in immune cell recognition, adhesion, signaling, and cellular interactions.
Optimal dilution of the ICAM1 Antibody ICAM1/6319 / Cell Adhesion Molecule Antibody should be determined by the researcher.
Recombinant full-length human ICAM1 protein was used as the immunogen for the ICAM1 Antibody ICAM1/6319. The epitope is is known to be in the extracellular domain.
Aliquot the ICAM1 Antibody ICAM1/6319 and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
ICAM1 antibody, ICAM-1 antibody, Intercellular adhesion molecule 1 antibody, CD54 antibody, Cell adhesion molecule antibody, LFA-1 ligand antibody, Major rhinovirus receptor antibody
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