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- Email: info@nsjbio.com
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Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy.
Titration of the Hopx antibody may be required due to differences in protocols and secondary/substrate sensitivity.
This mouse Hopx antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 22-54 amino acids from the Central region of mouse Hopx.
Aliquot the Hopx antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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