- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Herpes Simplex Virus Type I Antibody / HSV1 [clone HSVI/8375R] (V5324)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V5324-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
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V5324-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
|
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V5324SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
|
| Availability | 1-3 business days |
| Species Reactivity | Herpes Simplex Virus 1 |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | HSVI/8375R |
| Purity | Protein A affinity |
| Localization | Cytoplasm, Nucleus |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This Herpes Simplex Virus Type I antibody is available for research use only. |
|
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Herpes Simplex Virus Type I Antibody | HSV1 (clone HSVI/8375R) recognizes Herpes simplex virus type 1, an enveloped double stranded DNA virus classified within the Alphaherpesvirinae subfamily of the Herpesviridae family. HSV1 antibody, also referred to as HSV-1 antibody and Herpes simplex virus 1 antibody in the literature, detects viral antigens expressed during active replication and viral reactivation. Clone HSVI/8375R is produced as a recombinant rabbit monoclonal antibody, providing defined specificity and lot-to-lot consistency for HSV-1 detection in research settings.
Herpes simplex virus type 1 primarily infects epithelial cells of the oral and facial mucosa before establishing lifelong latency in sensory neurons, particularly within the trigeminal ganglia. During lytic infection, HSV-1 expresses immediate early, early, and late proteins that coordinate viral gene transcription, DNA replication, and virion assembly. Reactivation from latency leads to renewed viral protein synthesis and anterograde transport to peripheral tissues, resulting in recurrent lesions. Detection of HSV-1 antigen expression is therefore central to studies of viral replication dynamics and latency models.
The HSV-1 genome encodes numerous structural and regulatory proteins, including envelope glycoproteins such as gB, gC, gD, and gE, along with nuclear transcriptional regulators required for viral propagation. Viral antigens may localize to the nucleus, cytoplasm, or cellular membranes depending on the stage of infection. The recombinant rabbit monoclonal clone HSVI/8375R recognizes HSV-1 antigens and supports reproducible monoclonal detection of viral protein expression across experimental systems.
HSV-1 infection is associated with orolabial lesions, keratitis, encephalitis, and more severe disease in immunocompromised individuals. In research laboratories, HSV-1 is widely used to investigate viral latency, neuronal tropism, immune evasion mechanisms, and antiviral therapeutic development. A recombinant antibody format enables consistent performance and defined epitope recognition, supporting standardized experimental design.
Herpes Simplex Virus Type I Antibody | HSV1 (clone HSVI/8375R) is suitable for research applications focused on viral detection, host-pathogen interactions, and molecular analysis of Herpes simplex virus type 1 biology.
Optimal dilution of the Herpes Simplex Virus Type I antibody should be determined by the researcher.
Detergent-solubilized herpes simplex virus (HSV) type 1 infected cells were used as the immunogen for the Herpes Simplex Virus Type I antibody.
Aliquot the Herpes Simplex Virus Type I antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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