- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Hemoglobin Alpha Antibody / HBA1/2 Antibody (RQ6772)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ6772 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 449 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity purified |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | P69905 |
| Localization | Cytoplasmic, extracellular |
| Applications | Western Blot : 1-2ug/ml Immunohistochemistry (FFPE) : 2-5ug/ml |
| Limitations | This Hemoglobin Alpha Antibody / HBA1/2 Antibody is available for research use only. |
|
Review this product on BioCompare and get a $20 Amazon gift card
|
Related Products
|
Hemoglobin Alpha Antibody / HBA1/2 Antibody recognizes alpha-globin, a major protein component of adult hemoglobin. Human alpha-globin is encoded by the closely related HBA1 and HBA2 genes within the alpha-globin gene cluster on chromosome 16. The HBA1 and HBA2 proteins have identical amino acid sequences and associate with beta-like globin chains to form the tetrameric hemoglobin molecules responsible for oxygen transport in erythrocytes.
In adult red blood cells, alpha-globin primarily associates with beta-globin to form hemoglobin A (HbA; alpha2beta2), the predominant adult hemoglobin. Alpha-globin also associates with delta-globin to form the minor adult hemoglobin HbA2. During fetal development, alpha-globin pairs predominantly with gamma-globin to form fetal hemoglobin (HbF). The coordinated expression of globin genes during development is therefore essential for normal erythropoiesis and efficient oxygen transport.
Alpha-globin synthesis must remain balanced with production of its partner globin chains. Reduced or absent expression of HBA1 and/or HBA2 underlies alpha-thalassemia, a group of inherited hemoglobin disorders with severity influenced by the number and type of affected alpha-globin genes. Conversely, an excess of unpaired alpha-globin chains contributes to erythroid cell damage in beta-thalassemia. These relationships make hemoglobin alpha an important target in research involving erythropoiesis, hemoglobinopathies, red blood cell development and hematologic disease.
Beyond circulating erythrocytes, detection of alpha-globin can be useful for identifying erythroid cells and blood-associated components within tissues. Because hemoglobin is highly abundant in mature red blood cells, HBA1/2 expression provides a useful molecular indicator of erythroid differentiation and hemoglobin production.
This rabbit polyclonal antibody was generated against a synthetic peptide corresponding to the human alpha-globin sequence AVHASLDKFLASVSTVLTSKYR and is antigen affinity purified. It recognizes human and mouse HBA1/2. NSJ Bioreagents provides this Hemoglobin Alpha Antibody for research into erythroid biology, hemoglobin expression and oxygen transport. An HBA1/2 Antibody can support studies of alpha-globin expression, erythropoiesis and hemoglobin-associated disorders.
Explore our Antibodies page for additional primary antibodies targeting proteins involved in cell biology, metabolism, signaling and disease research.
Optimal dilution of the Hemoglobin Alpha Antibody / HBA1/2 Antibody should be determined by the researcher.
Amino acids AVHASLDKFLASVSTVLTSKYR from the human protein were used as the immunogen for the Hemoglobin Alpha Antibody.
After reconstitution, the Hemoglobin Alpha Antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Hemoglobin Alpha antibody, HBA1 antibody, HBA2 antibody, HBA1/2 antibody, alpha-globin antibody, hemoglobin subunit alpha antibody
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.
Powered by Bioz
