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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
hCG Receptor Antibody / LHCGR Polyclonal Antibody (R30629)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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R30629 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 449 |
| Species Reactivity | Human, Rat |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity |
| Buffer | Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal |
| UniProt | P22888 |
| Applications | Western blot: 0.5-1ug/ml Immunohistochemistry (FFPE): 0.5-1ug/ml |
| Limitations | This hCG Receptor Antibody / LHCGR Polyclonal Antibody is available for research use only. |
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hCG Receptor Antibody / LHCGR Polyclonal Antibody recognizes the luteinizing hormone/choriogonadotropin receptor, a G protein-coupled receptor encoded by the LHCGR gene. Also known as the luteinizing hormone receptor or lutropin receptor, LHCGR mediates cellular responses to luteinizing hormone (LH) and human chorionic gonadotropin (hCG). It belongs to the glycoprotein hormone receptor family and contains a large extracellular domain with leucine-rich repeats, seven transmembrane segments, and intracellular regions involved in signal transduction. This structural organization enables the receptor to recognize circulating hormones and initiate responses that regulate reproductive endocrine function.
Binding of LH or hCG activates LHCGR and stimulates intracellular signaling, primarily through Gs proteins and adenylyl cyclase. Increased cyclic AMP production activates protein kinase A-dependent pathways that regulate steroidogenic enzymes and cholesterol transport. The receptor can also engage additional signaling mechanisms, including beta-arrestin recruitment and mitogen-activated protein kinase activation. Receptor internalization, recycling, and desensitization help regulate the duration and intensity of hormonal responses.
In the ovary, LHCGR is expressed by theca cells, luteal cells, and granulosa cells during later stages of follicular maturation. LH-dependent signaling promotes androgen synthesis and contributes to the endocrine changes required for ovulation. Following the midcycle LH surge, receptor activation initiates luteinization and supports progesterone production by the corpus luteum. During early pregnancy, placental hCG maintains corpus luteum activity through LHCGR, sustaining progesterone secretion until placental steroidogenesis becomes sufficient.
In the testes, LHCGR is expressed predominantly by Leydig cells, where LH stimulation promotes testosterone biosynthesis. Testosterone supports male reproductive development, androgen-dependent physiological functions, and the hormonal environment required for spermatogenesis. Genetic alterations affecting LHCGR activity can disrupt reproductive endocrine regulation. Inactivating variants may impair gonadal steroidogenesis, while activating variants can produce ligand-independent signaling associated with certain forms of precocious puberty.
Beyond its established gonadal functions, LHCGR expression has been investigated in selected extragonadal tissues and hormone-responsive malignancies, although its physiological significance in these settings remains uncertain. Research examining receptor abundance, localization, and signaling regulation contributes to understanding endocrine physiology and hormone-dependent cellular responses. NSJ Bioreagents offers this hCG Receptor Antibody for investigating gonadotropin receptor biology, reproductive hormone signaling, and the molecular mechanisms governing steroidogenesis.
Explore our Luteinizing Hormone Receptor Antibody LHCGR/7399 for additional research tools targeting LHCGR and investigating reproductive endocrine signaling and gonadal steroidogenesis.
The stated application concentrations are suggested starting amounts. Titration of the hCG Receptor Antibody / LHCGR Polyclonal Antibody may be required due to differences in protocols and secondary/substrate sensitivity.
An amino acid sequence from the N-terminus of human hCG receptor (YLSICNTGIRKFPDVTK) was used as the immunogen for this hCG receptor antibody.
After reconstitution, the hCG receptor antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Luteinizing Hormone Receptor antibody, LH Receptor antibody, Choriogonadotropin Receptor antibody, Lutropin Receptor antibody, LHR antibody
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