- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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GST Mu 1 Antibody / Mu Class GST Antibody recognizes GSTM1, a cytosolic enzyme belonging to the mu class of glutathione S-transferases. GSTM1 contributes to cellular detoxification by catalyzing the conjugation of reduced glutathione to electrophilic compounds. This activity helps protect cells against reactive products generated by oxidative stress as well as environmental toxins, carcinogens and other xenobiotic compounds.
GSTM1 is part of a closely related group of mu class GST enzymes encoded by a gene cluster on chromosome 1. These enzymes participate in glutathione-dependent metabolism and cellular defense against potentially damaging chemical compounds. GSTM1 is therefore widely studied in research involving xenobiotic metabolism, oxidative stress, toxicology and cellular responses to environmental exposure.
The GSTM1 gene is highly polymorphic, and a common homozygous deletion produces the GSTM1-null genotype, resulting in absence of functional GSTM1 protein. This variation has been extensively investigated in relation to individual differences in detoxification capacity and susceptibility to environmental carcinogens. GSTM1 genetic status has consequently been examined in cancer susceptibility, drug response and other conditions influenced by oxidative or chemical stress. Multiple transcript variants of GSTM1 have also been described.
Clone CPTC-GSTMu1-3 is a mouse monoclonal antibody generated against full-length recombinant human GSTM1 and purified by Protein G affinity chromatography. NSJ Bioreagents provides this GST Mu 1 Antibody for research into GSTM1 expression, glutathione-dependent detoxification and cellular defense mechanisms. A Mu Class GST Antibody recognizing GSTM1 can support studies of this enzyme and its role in xenobiotic metabolism and oxidative stress responses.
For additional reagents and information on GSTM1-mediated detoxification and oxidative stress responses, visit our GSTM1 Antibody / Glutathione S-Transferase Mu 1 Antibody page.
Optimal dilution of the GST Mu 1 Antibody / Mu Class GST Antibody should be determined by the researcher.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Full length recombinant human protein was used as the immunogen for this GSTM1 antibody.
Store the GSTM1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
GST Mu 1 antibody, GSTM1 antibody, glutathione S-transferase Mu 1 antibody, Mu Class GST antibody
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