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Home >> Antibodies >> Glypican 3 Antibody

Glypican 3 Antibody (F49599)

  Catalog No Formulation Size Price (USD)  
Image F49599-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 399
Image
F49599-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 185
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Glypican 3 antibody western blot analysis in mouse stomach tissue lysate
Glypican 3 antibody western blot analysis in HepG2 lysate
Glypican 3 antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue.
Availability 1-3 business days
Species Reactivity Human, Mouse
Format Purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Purified
UniProt P51654
Applications Western blot : 1:1000
IHC (Paraffin) : 1:50-1:100
Limitations This Glypican 3 antibody is available for research use only.
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Description

GPC3 is a cell surface proteoglycan that bears heparan sulfate. This protein may be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs, and may play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. Members of the glypican-related integral membrane proteoglycan family contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol (GPI) linkage. These proteins may play a role in the control of cell division, growth regulation, and tumor predisposition. Deletion mutations in GPC3 are the cause of Simpson-Golabi-Behmel syndrome (SGBS), also known as Simpson dysmorphia syndrome (SDYS). SGBS is a condition characterized by pre- and postnatal overgrowth (gigantism) with visceral and skeletal anomalies.

Application Notes

Titration of the Glypican 3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 21-50 from the human protein was used as the immunogen for this Glypican 3 antibody.

Storage

Aliquot the Glypican 3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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