GAD65 Antibody / Synaptic GABA Marker Antibody [clone GAD2/2362] (V7506)

GAD65 Antibody Pancreas IHC. Immunohistochemistry analysis of FFPE human pancreas tissue stained with GAD65 Antibody demonstrates cytoplasmic HRP-DAB brown staining within scattered islet-associated endocrine cell populations, consistent with Glutamate decarboxylase 65 / GAD2 expression in inhibitory neurotransmitter-associated secretory cells. This synaptic GABA marker antibody highlights GABA synthesis-associated signaling pathways and neuroendocrine regulatory biology within pancreatic tissue. Required HIER: boil tissue sections in 10mM citrate buffer, pH 6, for 10-20 min and allow to cool prior to testing.

GAD65 Antibody HuProt Microarray Validation. Analysis of HuProt(TM) microarray containing more than 19,000 full-length human proteins using GAD65 Antibody demonstrates highly selective recognition of GAD65 / GAD2 with strong separation from non-target proteins across the tested human proteome. These results demonstrate the foremost specificity of the GAD2/2362 mAb and support highly specific detection of inhibitory neurotransmitter-associated signaling pathways and synaptic GABAergic neuronal markers. The Z-score represents the strength of antibody binding signal relative to the overall array mean, while the S-score reflects target specificity relative to the next highest ranked protein signal. The markedly elevated S-score separation observed for GAD2 supports preferential target recognition with minimal off-target binding across the tested human proteome.

SDS-PAGE analysis of purified, BSA-free GAD65 antibody (clone GAD2/2362) as confirmation of integrity and purity.