- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
FSHB Antibody / Pituitary Gonadotropin Hormone Antibody [clone FLTPb-1] (V7078)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V7078-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
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V7078-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V7078SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 | |
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V7078IHC-7ML | Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only* | 7 ml | 559 |
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| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | FLTPb-1 |
| Purity | Protein G affinity chromatography |
| UniProt | P01225 |
| Localization | Cytoplasmic, secreted |
| Applications | Immunohistochemistry (FFPE) : 0.5-1ug/ml for 30 min at RT Prediluted IHC Only Format : incubate for 30 min at RT (1) |
| Limitations | This FSHB Antibody / Pituitary Gonadotropin Hormone Antibody is available for research use only. |
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Follicle stimulating hormone beta (FSHB) is the beta subunit component of follicle stimulating hormone (FSH), a pituitary-derived gonadotropin involved in reproductive endocrine regulation, gonadal development, and fertility-associated signaling pathways. FSHB Antibody / Pituitary Gonadotropin Hormone Antibody recognizes the hormone-specific beta subunit responsible for biologic specificity of follicle stimulating hormone within the hypothalamic-pituitary-gonadal endocrine axis.
FSHB antibody, also referred to as Follicle stimulating hormone beta antibody and FSH beta antibody in the literature, is widely used in pituitary biology, endocrine pathology, reproductive signaling, and neuroendocrine research applications. Monoclonal clone FLTPb-1 supports investigation of gonadotroph-associated hormone expression and pituitary endocrine cell populations involved in reproductive hormone synthesis and secretion.
FSH is synthesized and secreted by anterior pituitary gonadotroph cells in response to hypothalamic gonadotropin releasing hormone (GnRH) signaling. The mature hormone consists of a shared alpha subunit paired with the hormone-specific FSH beta subunit encoded by FSHB. Expression of the beta subunit determines biologic specificity and functional regulation of follicle stimulating hormone activity within reproductive endocrine pathways.
In females, FSH signaling regulates ovarian follicular development, granulosa cell proliferation, estrogen biosynthesis, and ovulatory cycle-associated endocrine regulation. In males, FSH contributes to Sertoli cell function and spermatogenesis-associated signaling within the testis. Because of these central endocrine roles, FSHB-associated signaling pathways are critical for reproductive physiology and fertility regulation.
FSHB expression is primarily localized to anterior pituitary gonadotroph cells where hormone synthesis occurs within secretory granule-associated cytoplasmic compartments. Immunohistochemistry staining with FSHB antibodies commonly demonstrates granular cytoplasmic staining patterns in scattered anterior pituitary endocrine cells corresponding to gonadotroph-associated hormone production.
In endocrine pathology and pituitary adenoma research, FSHB antibodies are frequently used for characterization of gonadotroph lineage-associated tumors and hormone-producing pituitary neoplasms. Detection of FSH beta expression contributes to classification of pituitary endocrine cell differentiation patterns and gonadotropin-associated hormone production states.
Because FSH signaling is tightly integrated with reproductive endocrine regulation, FSHB-associated pathways remain important in studies examining fertility biology, reproductive aging, endocrine signaling disorders, and pituitary hormone regulation mechanisms. The restricted expression profile of FSHB within pituitary gonadotroph populations further supports its value as a selective endocrine lineage marker.
Together, the available immunohistochemistry data support the use of FSHB antibody clone FLTPb-1 for investigating pituitary gonadotropin biology, reproductive endocrine signaling pathways, and gonadotroph-associated hormone expression.
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Optimal dilution of the FSHB Antibody / Pituitary Gonadotropin Hormone Antibody should be determined by the researcher.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Recombinant hFSH beta subunit was used as the immunogen for the FSH-beta antibody. It does not cross-react with the alpha subunit
Store the FSH-beta antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
FSHB antibody, Follicle stimulating hormone beta antibody, FSH beta antibody, gonadotropin hormone antibody, pituitary hormone marker antibody
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