- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Frizzled 2 Antibody (R35814)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
R35814-100UG | 0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide | 100 ug | 475 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Predicted Reactivity | Mouse, Rat |
| Format | Antigen affinity purified |
| Host | Goat |
| Clonality | Polyclonal (goat origin) |
| Isotype | Goat Ig |
| Purity | Antigen affinity |
| Gene ID | 2535 |
| Localization | Cytoplasmic, membrane |
| Applications | Immunohistochemistry (FFPE) : 2.5-5ug/ml ELISA (peptide) LOD : 1:64000 |
| Limitations | This Frizzled 2 antibody is available for research use only. |
|
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Frizzled 2 Antibody / Wnt Receptor Antibody recognizes Frizzled 2 (FZD2), a seven-transmembrane receptor that serves as a key mediator of Wnt signaling. Upon binding Wnt ligands, FZD2 activates both canonical beta-catenin-dependent and non-canonical signaling pathways that regulate cell proliferation, differentiation, migration, polarity, and survival. These highly conserved signaling mechanisms are essential for embryonic development, tissue homeostasis, and regeneration, making FZD2 an important target for developmental biology, stem cell, and cancer research. Frizzled 2 Antibody / Wnt Receptor Antibody enables reliable detection of FZD2 expression across a wide range of experimental applications.
FZD2 is widely expressed during vertebrate development, where it contributes to gastrulation, neural tube formation, craniofacial development, limb patterning, and organogenesis. Through regulation of planar cell polarity signaling, FZD2 coordinates directional cell movement and tissue organization required for proper morphogenesis. In adult tissues, FZD2 continues to regulate epithelial maintenance, stem cell function, and tissue repair by integrating extracellular Wnt signals with intracellular signaling cascades that govern cell fate decisions and structural organization.
Aberrant FZD2 expression has been implicated in numerous human diseases, particularly cancer. Increased FZD2 activity has been associated with epithelial-to-mesenchymal transition, enhanced tumor cell migration, invasion, metastasis, and resistance to therapy in several malignancies. Because of these diverse biological functions, FZD2 has emerged as both a potential prognostic biomarker and an attractive therapeutic target for modulation of Wnt signaling. Ongoing research also continues to investigate its involvement in fibrosis, wound healing, and developmental disorders linked to dysregulated Wnt pathway activity.
NSJ Bioreagents' Frizzled 2 Antibody / Wnt Receptor Antibody provides a dependable reagent for investigating one of the central receptors within the Wnt signaling network. Suitable for applications including immunohistochemistry, western blotting, immunofluorescence, and flow cytometry, this antibody supports studies of embryonic development, tissue regeneration, signal transduction, stem cell biology, and oncology. Researchers use Frizzled 2 Antibody / Wnt Receptor Antibody to characterize receptor expression, cellular localization, and alterations in Wnt signaling across both normal physiology and disease.
Explore additional antibodies targeting Wnt signaling and related pathways on our Signal Transduction Antibodies page.
Optimal dilution of the Frizzled 2 antibody should be determined by the researcher.
Amino acids RYATLEHPFHCPR were used as the immunogen for this Frizzled 2 antibody.
Aliquot and store the Frizzled 2 antibody at -20oC.
Frizzled 2 antibody, FZD2 antibody, Frizzled-2 antibody, Wnt Receptor FZD2 antibody, Frizzled Family Receptor 2 antibody, Seven Transmembrane Receptor FZD2 antibody
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