- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
ETV6 Antibody / TEL Transcription Factor Antibody is useful for investigating one of the most important ETS family transcriptional repressors involved in hematopoiesis, embryonic development, and chromosomal stability. ETV6, historically known as TEL (Translocation-Ets-Leukemia), is a ubiquitously expressed nuclear protein that functions primarily as a transcriptional repressor through its amino-terminal pointed (PNT) oligomerization domain and carboxyl-terminal ETS DNA-binding domain. By regulating gene expression programs that control cell proliferation, differentiation, and survival, ETV6 plays an essential role in normal blood cell development and maintenance of tissue homeostasis.
ETV6 is particularly well known for its involvement in hematologic malignancies. Chromosomal translocations involving the ETV6 gene on chromosome 12p13 generate numerous fusion proteins, including the clinically important ETV6-RUNX1 fusion found in a substantial proportion of pediatric B-cell acute lymphoblastic leukemia. Additional fusion partners include ABL1, PDGFRB, JAK2, NTRK3, and FLT3, among many others, linking ETV6 to diverse leukemias, myeloproliferative neoplasms, sarcomas, and secretory carcinomas. Beyond fusion events, inherited and somatic ETV6 mutations have been associated with thrombocytopenia, predisposition to hematologic cancers, and altered stem cell function. These findings have established ETV6 as both a critical developmental regulator and an important cancer-associated gene.
In normal physiology, ETV6 participates in transcriptional networks that influence hematopoietic stem cell maintenance, vascular development, and mesenchymal differentiation. Through interactions with transcriptional co-repressors and chromatin remodeling complexes, it suppresses target gene expression while coordinating lineage commitment and cellular maturation. Loss or disruption of ETV6 function can result in abnormal proliferation, impaired differentiation, and genomic instability, emphasizing its importance as a tumor suppressor in many biological contexts. Consequently, ETV6 continues to be extensively studied in developmental biology, leukemia research, molecular pathology, and investigations of oncogenic signaling pathways.
An ETV6 Antibody is a valuable tool for detecting endogenous ETV6 expression by western blotting, immunohistochemistry, immunofluorescence, immunoprecipitation, flow cytometry, and related laboratory applications. Because of the central role of the TEL transcription factor in hematopoiesis, gene regulation, and recurrent cancer-associated chromosomal rearrangements, an ETV6 Antibody supports studies of normal development, leukemia biology, and transcriptional control.
Researchers studying leukemia-associated transcription factors, chromosomal rearrangements, and oncogenic signaling pathways may also be interested in browsing our Cancer Marker Antibodies page for additional validated research antibodies.
Optimal dilution of the ETV6 Antibody / TEL Transcription Factor Antibody should be determined by the researcher.
A recombinant human partial protein corresponding to amino acids E327-Q448 was used as the immunogen for the ETV6 antibody.
After reconstitution, the ETV6 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
ETV6 antibody, ETS Variant Transcription Factor 6 antibody, TEL antibody, Translocation-Ets-Leukemia antibody, ETS-related protein TEL antibody
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