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Home >> Antibodies >> E2F1 Antibody

E2F1 Antibody (F50541)

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  Catalog No Formulation Size Price (USD)  
Image F50541-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 399
Image
F50541-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 185
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Western blot analysis of E2F1 antibody and 293 lysate. Predicted molecular weight: 48-70 kDa.
Western blot analysis of E2F1 antibody and 293 lysate. Predicted molecular weight: 48-70 kDa.
Availability 1-3 business days
Species Reactivity Human
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt Q01094
Applications Western blot : 1:1000
Limitations This E2F1 antibody is available for research use only.
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Description

E2F1 is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another two members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.

Application Notes

Titration of the E2F1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 310-344 from the human protein was used as the immunogen for this E2F1 antibody.

Storage

Aliquot the E2F1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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