DNMT3A Antibody / De Novo DNA Methylation Enzyme Antibody [clone PCRP-DNMT3A-1E2] (V3827)

DNMT3A Antibody Placenta IHC. Immunohistochemistry analysis of FFPE human placental tissue using DNMT3A Antibody shows nuclear staining in trophoblast and stromal cell populations, consistent with localization of DNMT3A / DNA methyltransferase 3 alpha as a nuclear epigenetic regulator. Staining is observed within cell nuclei lining placental structures, reflecting active de novo DNA methylation processes during development. Hematoxylin counterstain provides nuclear contrast and tissue architecture. HIER: boil FFPE tissue sections in 1 mM EDTA, pH 9, for 10-20 min and allow to cool before testing.

DNMT3A Antibody Placental Tissue IHC. Immunohistochemistry analysis of FFPE human placental tissue using DNMT3A Antibody shows nuclear staining in trophoblast cells and scattered stromal populations, consistent with localization of DNMT3A / DNA methyltransferase 3 alpha as a nuclear epigenetic regulator. Signal intensity varies across placental regions, with positive nuclei outlining villous structures, reflecting active de novo DNA methylation in developing tissue. Hematoxylin counterstain provides nuclear contrast and tissue architecture. HIER: boil FFPE tissue sections in 1 mM EDTA, pH 9, for 10-20 min and allow to cool before testing.

DNMT3A Antibody HuProt Microarray Specificity. Protein microarray analysis using DNMT3A Antibody (clone PCRP-DNMT3A-1E2) demonstrates highly specific binding to DNMT3A / DNA methyltransferase 3 alpha, with the target protein ranked as the top hit and showing a strong Z score with clear separation from all other proteins on the array. Signal intensity decreases sharply for non-target proteins, supporting selective recognition with minimal off-target interaction. Z score represents the strength of signal in standard deviations above the mean of all array signals, while S score reflects the separation between ranked targets and provides a measure of relative specificity.

SDS-PAGE analysis of purified, BSA-free DNMT3A antibody as confirmation of integrity and purity.