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Home >> Antibodies >> DMRT2 Antibody

DMRT2 Antibody [clone PCRP-DMRT2-1B11] (V9601)

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  Catalog No Formulation Size Price (USD)  
Image V9601-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 519
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V9601-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V9601SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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Analysis of HuProt(TM) microarray containing more than 19,000 full-length human proteins using DMRT2 antibody (clone PCRP-DMRT2-1B11). These results demonstrate the foremost specificity of the PCRP-DMRT2-1B11 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt(TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt(TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.
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Analysis of HuProt(TM) microarray containing more than 19,000 full-length human proteins using DMRT2 antibody (clone PCRP-DMRT2-1B11). These results demonstrate the foremost specificity of the PCRP-DMRT2-1B11 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt(TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt(TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.
FACS staining of PFA-fixed human HeLa cells with DMRT2 antibody (blue, clone PCRP-DMRT2-1B11) and isotype control (red).
SDS-PAGE analysis of purified, BSA-free DMRT2 antibody (clone PCRP-DMRT2-1B11) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG2b
Clone Name PCRP-DMRT2-1B11
Purity Protein A/G affinity
UniProt Q9Y5R5
Localization Nucleus
Applications Flow cytometry : 1-2ug/million cells
Western blot : 1-2ug/ml
Limitations This DMRT2 antibody is available for research use only.
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Description

The protein encoded by this gene belongs to the DMRT gene family, sharing a DM DNA-binding domain with Drosophila (dsx) and C. elegans mab3, genes involved in sex determination in these organisms. Also, this gene is located in a region of the human genome (chromosome 9p24.3) associated with gonadal dysgenesis and XY sex reversal. Hence this gene is one of the candidates for sex-determining gene(s) on chr 9. Transcriptional activator that directly regulates early activation of the myogenic determination gene MYF5 by binding in a sequence-specific manner to the early epaxial enhancer element of it. Involved in somitogenesis during embryogenesis and somite development and differentiation into sclerotome and dermomyotome. Required for the initiation and/or maintenance of proper organization of the sclerotome, dermomyotome and myotome (By similarity).

Application Notes

Optimal dilution of the DMRT2 antibody should be determined by the researcher.

Immunogen

Recombinant full-length human DMRT2 protein was used as the immunogen for the DMRT2 antibody.

Storage

Aliquot the DMRT2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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