Delta-Sarcoglycan Antibody Biotin Conjugate (R35676BTN)

Description

Delta-Sarcoglycan Antibody Biotin Conjugate recognizes delta-sarcoglycan, the transmembrane glycoprotein encoded by the SGCD gene and an essential component of the sarcoglycan complex within the dystrophin-associated glycoprotein complex. Delta-sarcoglycan is expressed predominantly in skeletal, cardiac, and smooth muscle, where it helps maintain sarcolemmal stability by linking the intracellular cytoskeleton to the extracellular matrix. This structural role protects muscle fibers from mechanical stress generated during repeated contraction and relaxation. The biotin conjugate format is well suited for sensitive protein detection methods that utilize streptavidin-based detection systems.

Delta-sarcoglycan assembles with alpha, beta, and gamma sarcoglycan to form a membrane-associated complex that is required for normal muscle function. Proper formation of this complex is critical for stabilizing the dystrophin-associated glycoprotein complex and preserving muscle membrane integrity. Disruption of any sarcoglycan subunit can destabilize the entire complex, leading to increased membrane fragility and progressive muscle degeneration. Consequently, Delta-Sarcoglycan Antibody Biotin Conjugate is valuable for studies of sarcolemma organization, membrane protein localization, muscle development, and the molecular architecture of skeletal and cardiac muscle.

Mutations in SGCD are associated with autosomal recessive limb-girdle muscular dystrophy and have also been linked to cardiomyopathy. Loss of delta-sarcoglycan disrupts the sarcoglycan complex, impairing membrane stability and increasing susceptibility to contraction-induced muscle injury. As a result, SGCD is widely investigated in research focused on inherited muscular dystrophies, cardiac muscle disorders, regenerative medicine, and emerging therapeutic strategies including gene replacement and genome editing. The biotin-conjugated format facilitates flexible detection workflows and multiplex assays in studies of muscle biology and disease.

Delta-sarcoglycan is commonly analyzed by Western blotting, immunohistochemistry, immunofluorescence, immunoprecipitation, and related protein detection techniques using skeletal and cardiac muscle as positive control tissues. A Delta-Sarcoglycan Antibody Biotin Conjugate is a valuable research tool for detecting endogenous SGCD expression and investigating sarcoglycan biology, dystrophin-associated protein complexes, muscle membrane stability, muscular dystrophy, and skeletal and cardiac muscle physiology.

Learn more about SGCD biology and its role within the sarcoglycan complex by visiting our SGCD Antibody / Sarcoglycan Family Protein Antibody page.

Application Notes

Optimal dilution of the Delta-Sarcoglycan Antibody Biotin Conjugate should be determined by the researcher.

1. This delta-Sarcoglycan antibody will detect isoforms 1 and 3.

Immunogen

Amino acids RLPHGSYTPTGTR were used as the immunogen for this delta-Sarcoglycan antibody. This sequence is specific to isoforms 1 and 3.

Storage

Aliquot and store the delta-Sarcoglycan antibody at -20oC.