- Tel: 858.663.9055
- Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CYP3A5 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. The enzyme metabolizes drugs such as nifedipine and cyclosporine as well as the steroid hormones testosterone, progesterone and androstenedione.
The stated application concentrations are suggested starting points. Titration of the Cytochrome P450 3A5 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 476-502 from the human protein was used as the immunogen for the Cytochrome P450 3A5 antibody.
Aliquot the Cytochrome P450 3A5 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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