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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CYLD Antibody (N1164)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
N1164-100UG | 0.5 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 439 |
|
| Species Reactivity | Human, Mouse |
| Format | Purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Protein A affinity chromatography |
| Buffer | 1X PBS, pH 7.4 |
| Gene ID | 1540 |
| Applications | Western Blot : 2-5ug/ml |
| Limitations | This CYLD antibody is available for research use only. |
|
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CYLD Antibody detects CYLD, a protein involved in multiple physiological processes including immune response, osteoclastogenesis and spermatogenesis. It is a tumor suppressor via its negative regulation of NF-kB activation. CYLD is a deubiquitinase, removing ubiquitin chains from tumor-necrosis factor receptor-associated factor 2 (TRAF2) and thereby preventing its activation of IkB, a regulator of NF-kB. NF-kB remains sequestered in the cytoplasm, unable to translocate to the nucleus and initiate cell survival and oncogenetic signaling.
For a broader overview of CYLD biology, deubiquitinase function, and ubiquitin-dependent signaling, see our CYLD Antibody / Deubiquitinase Antibody page.
Provided assay concentrations are suggestions only, CYLD antibody titration may be required for optimal results.
A recombinant protein fragment from the N-termiinal region of human CYLD was used as the immunogen for this antibody.
Aliquot the CYLD antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Cylindromatosis, BRSS, CDMT antibody
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