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Home >> Antibodies >> CLEC4E Antibody

CLEC4E Antibody (N1058)

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  Catalog No Formulation Size Price (USD)  
Image N1058-100UG 0.5 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 429
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N1058-25UG 0.5 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 25 ug 219
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CLEC4E antibody western blot of human samples
Western blot testing of human samples with CLEC4E antibody at 2ug/ml.
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Protein A affinity chromatography
Buffer 1X PBS, pH 7.4
Gene ID 26253
Applications Western blot : 2-5ug/ml
Limitations This CLEC4E antibody is available for research use only.
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Description

CLEC4 is a member of the C-type lectin family of proteins that plays a role in inflammatory and immune response. CLEC4E, also called Mincle (Macrophage-inducible C-type lectin), is found on the surface of activated macrophages and phagocytes. It is a receptor for both non-self (fungi and mycobacteria), and self (damaged cells) ligands. Dead cells release SAP130 (Sin3A-Associated Protein, 130kDa), a small nuclear ribonucleoprotein component. CLEC4E senses this and interacts with the ITAM-containing adaptor protein FcRγ, and via Syk and CARD9 signaling, activates the production of inflammatory cytokines such as TNFa, MIP-2 and IL-6.

Application Notes

Provided assay concentrations are suggestions only, CLEC4E antibody titration may be required for optimal results.

Immunogen

A recombinant protein fragment from the C-terminal portion of human CLEC4E was used as the immunogen for this antibody.

Storage

Aliquot the CLEC4E antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Alternate Names

C-type lectin domain family 4 member E, Macrophage-inducible C-type lectin, MINCLE antibody

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