CHMP2B Antibody / Charged multivesicular body protein 2b [clone 25C36] (RQ8902)

Description

Charged multivesicular body protein 2b (CHMP2B) is a component of the endosomal sorting complex required for transport III (ESCRT-III). It plays a critical role in multivesicular body formation, membrane fission, and the sorting of ubiquitinated proteins for lysosomal degradation. CHMP2B is essential for maintaining proper endosomal trafficking and cellular protein homeostasis.

Mutations in CHMP2B have been linked to neurodegenerative disorders, including frontotemporal dementia and amyotrophic lateral sclerosis. Research on CHMP2B helps elucidate mechanisms of vesicular transport, neuronal maintenance, and protein quality control, making it relevant in both basic and disease-focused studies.

Using a high-quality CHMP2B antibody enables accurate detection in applications such as western blot, immunohistochemistry, and immunofluorescence. A CHMP2B antibody from NSJ Bioreagents provides reliable and reproducible performance for studies in membrane trafficking, neurodegeneration, and cellular signaling. Selecting the right CHMP2B antibody is essential for obtaining consistent and meaningful results.

Application Notes

Optimal dilution of the CHMP2B antibody should be determined by the researcher.

Immunogen

A peptide sequence specific to Charged multivesicular body protein 2b protein was used as the immunogen for the CHMP2B antibody.

Storage

After reconstitution, the CHMP2B antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.