- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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CD68 Antibody / Macrophage Marker Antibody recognizes CD68, a highly glycosylated lysosomal membrane protein that is widely used as a marker of macrophages, monocytes and other cells of the mononuclear phagocyte system. CD68 belongs to the lysosome-associated membrane glycoprotein family and is primarily localized within intracellular endosomes and lysosomes, although limited surface expression has also been reported in activated cells. Owing to its abundant expression in tissue macrophages, CD68 has become one of the most frequently used markers for identifying macrophage populations in normal tissues and disease. NSJ Bioreagents provides CD68 antibodies for studies of innate immunity, inflammation, tissue remodeling and macrophage biology.
CD68 is expressed by resident macrophages in numerous organs, including liver, spleen, lung, lymph node, bone marrow and central nervous system, where it is prominently detected in Kupffer cells, alveolar macrophages and microglia. The protein participates in lysosomal function, phagocytosis, endocytic trafficking and clearance of cellular debris. Because macrophages exhibit remarkable functional diversity across tissues, CD68 remains an essential marker for investigating macrophage localization, abundance and activation during development, homeostasis and immune responses.
Altered CD68 expression is associated with a broad range of pathological conditions including chronic inflammation, infectious disease, autoimmune disorders, atherosclerosis, neurodegeneration and cancer. Quantification of CD68-positive macrophages is commonly used to evaluate immune cell infiltration within tumors and inflamed tissues, providing valuable insight into disease progression and the tissue microenvironment. Consequently, CD68 is extensively employed in immunology, oncology, pathology and neuroscience research to characterize macrophage distribution and innate immune activity.
An CD68 Antibody is a valuable reagent for detecting macrophages by Western blotting, immunohistochemistry, immunofluorescence, flow cytometry and related immunoassays. A Macrophage Marker Antibody supports investigations of innate immunity, phagocyte biology, inflammatory responses and tissue-resident macrophage populations.
Researchers studying leukocyte phenotyping and immune cell identification may also be interested in our CD Antibodies page, featuring antibodies against clusters of differentiation (CD) markers used in immunology, hematology, oncology and flow cytometry research.
Optimal dilution of the CD68 Antibody / Macrophage Marker Antibody should be determined by the researcher.
A portion of amino acids 150-301 from the human protein was used as the immunogen for the CD68 antibody.
Store the CD68 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
CD68 antibody, Macrophage Marker antibody, Macrosialin antibody, Lysosomal Glycoprotein antibody
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