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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Recognizes a protein of 205kDa-220kDa, identified as CD45RA. CD45RA is isoforms of the human leukocyte common antigen (CD45). Human CD45 contains three exons which encode peptide segments designated A, B and C, respectively. The differential splicing of the exons generates at least five isoforms, ABC, AB, BC, B and O. This antibody reacts with ABC and BC isoforms. CD45RA is expressed on 40-50% of peripheral CD4+ T-cells, 50% of peripheral CD8+ T-cells, B-cells, and leukemic B-cell lines. T-cells expressing CD45RA are naive or virgin T-cells. T-cells expressing CD45RO are memory T-cells. CD45RA and CD45RO define complementary, predominantly non-overlapping populations of resting peripheral T-cells. This MAb is useful in study on the subpopulation of CD4+ or CD8+ T-cells. It can especially be used to differentiate T-cell lymphomas (CD45RO +ve) from B cell lymphomas (CD45RA +ve).
CD45RA is an alternatively spliced form of PTPRC widely studied in lymphocyte differentiation and immune cell phenotyping; learn more about the target and related reagents on our CD45RA Antibody page.
Optimal dilution of the CD45RA antibody should be determined by the researcher.
Stimulated human leukocytes were used as the immunogen for the CD45RA antibody.
Store the CD45RA antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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