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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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CD25 Antibody specifically recognizes a protein of 55 kDa, identified as CD25. It is expressed on activated T- and B-cells and activated monocytes/macrophages. With respect to lymphomas, CD25 is present on malignant cells of Hodgkins disease, HTLV-1+ adult T-cell leukemia, cutaneous T-cell lymphoma, and hair cell leukemia. Increased levels of soluble CD25 are observed in the leukemias/lymphomas and inflammatory/ autoimmune diseases. CD25 molecule alone appears to function as a low affinity receptor and associates with CD122 (IL-2R b-chain, p75) and CD132 (common g-chain) to form the high affinity IL-2 receptor complex. CD25 antibodies detect three epitope regions, A, B and C. This mAb recognizes the epitope B, which is located at residue 3-104 of CD25 and does not block IL-2 binding to CD25.
Explore the broader CD Antibodies page for additional antibodies targeting leukocyte differentiation markers, immune receptors, and cell surface proteins involved in innate and adaptive immune signaling pathways.
Optimal dilution of the CD25 antibody should be determined by the researcher.
This mAb recognizes the epitope B, which is located at residue 3-104 of CD25 and does not block IL-2 binding to CD25.
A portion of amino acids 42-183 was used as the immunogen for the CD25 antibody.
Store the CD25 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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