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Home >> Antibodies >> Caspase-3 Antibody

Caspase-3 Antibody (F48960)

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  Catalog No Formulation Size Price (USD)  
Image F48960-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 399
Image
F48960-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 185
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Caspase-3 antibody WB and CEM lysate. Expected size ~32 KDa
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Caspase-3 antibody WB and CEM lysate. Expected size ~32 KDa
Caspase-3 antibody IHC analysis in formalin fixed and paraffin embedded human brain tissue.
Western blot analysis of Caspase-3 antibody and 293 cell lysate (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (2) with the CASP3 gene.
Caspase-3 antibody flow cytometric analysis of CEM cells (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary Ab was used for the analysis.
Availability 1-3 business days
Species Reactivity Human
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt P42574
Applications Western blot : 1:1000
IHC (Paraffin) : 1:50-1:100
Flow Cytometry : 1:10-1:50
Limitations This Caspase-3 antibody is available for research use only.
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Description

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.

Application Notes

Titration of the Caspase-3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 149-179 from the human protein was used as the immunogen for this Caspase-3 antibody.

Storage

Aliquot the Caspase-3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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