- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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BMAL1 Antibody / Circadian Clock Protein Antibody recognizes Brain and Muscle ARNT-Like 1 (BMAL1), a basic helix-loop-helix PAS domain-containing transcription factor that serves as a master regulator of the mammalian circadian clock. BMAL1 forms a heterodimer with CLOCK to drive rhythmic transcription of numerous clock-controlled genes, thereby coordinating daily oscillations in metabolism, hormone secretion, immune responses and behavior. Through this central role, BMAL1 helps synchronize cellular functions with environmental light-dark cycles and contributes to the maintenance of physiological homeostasis. NSJ Bioreagents offers BMAL1 antibodies for researchers investigating circadian biology, transcriptional regulation and metabolic signaling.
BMAL1 is widely expressed throughout the body and functions as a core component of the molecular clock in both central and peripheral tissues. Its transcriptional activity regulates genes involved in sleep-wake cycles, energy metabolism, cell proliferation, DNA repair and oxidative stress responses. Disruption of BMAL1 expression or circadian timing has been associated with metabolic disorders, cardiovascular disease, neurodegeneration, inflammation and cancer. Because circadian regulation influences numerous physiological systems, BMAL1 has become an important target for studies of aging, tissue homeostasis and chronobiology.
Current research examines how BMAL1 coordinates rhythmic gene expression through interactions with CLOCK, CRY and PER proteins, as well as additional transcriptional regulators and signaling pathways. Investigators also explore how altered BMAL1 activity affects stem cell maintenance, immune cell function and responses to environmental stress. Measuring BMAL1 expression can provide valuable insight into circadian clock regulation, disease mechanisms and therapeutic approaches that target biological timing or metabolic pathways.
An BMAL1 Antibody is a valuable reagent for detecting this circadian clock protein by Western blotting, immunohistochemistry, immunofluorescence, flow cytometry and related immunoassays. By enabling reliable analysis of protein expression and cellular localization, an BMAL1 Antibody supports investigations into circadian rhythm regulation, transcriptional control and clock-dependent physiology.
Researchers studying circadian gene regulation may also be interested in our Transcription Factor Antibodies page, featuring antibodies against transcriptional regulators involved in development, metabolism, cell signaling and gene expression.
Optimal dilution of the BMAL1 Antibody / Circadian Clock Protein Antibody should be determined by the researcher.
A human recombinant protein (amino acids R116-E447) was used as the immunogen for the BMAL1 antibody.
After reconstitution, the BMAL1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
BMAL1 antibody, ARNTL antibody, Brain and Muscle ARNT-Like 1 antibody, Aryl Hydrocarbon Receptor Nuclear Translocator Like antibody, Class E Basic Helix-Loop-Helix Protein 5 antibody, BHLHE5 antibody, MOP3 antibody, JAP3 antibody, PASD3 antibody
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