- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
BACE2 Antibody (F49441)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
F49441-0.4ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.4 ml | 399 | |
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F49441-0.08ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.08 ml | 185 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Purity | Purified |
| UniProt | Q9Y5Z0 |
| Applications | Western blot : 1:1000 Flow Cytometry : 1:10-1:50 |
| Limitations | This BACE2 antibody is available for research use only. |
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Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by BACE2. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease.
Titration of the BACE2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 336-365 from the human protein was used as the immunogen for this BACE2 antibody.
Aliquot the BACE2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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