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Home >> Antibodies >> Axin-1 Antibody

Axin-1 Antibody (F41872)

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  Catalog No Formulation Size Price (USD)  
Image F41872-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 399
Image
F41872-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 185
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Axin-1 antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue
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Axin-1 antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue
Axin-1 antibody western blot analysis in MDA-MB435 lysate. Predicted molecular weight: 95-110 kDa.
Availability 1-3 business days
Species Reactivity Human
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt O15169
Applications Western blot : 1:1000
IHC (Paraffin) : 1:10-1:50
Limitations This Axin-1 antibody is available for research use only.
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Description

Axin-1 is a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for the gene.

Application Notes

Titration of the Axin-1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 710-738 from the human protein was used as the immunogen for this Axin-1 antibody.

Storage

Aliquot the Axin-1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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