- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
APOE Antibody / Apolipoprotein E [clone APOE/3673] (V5402)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V5402-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V5402-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V5402SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | APOE/3673 |
| Purity | Protein A/G affinity |
| UniProt | P02649 |
| Localization | Secreted |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml Western Blot : 2-4ug/ml |
| Limitations | This APOE antibody is available for research use only. |
|
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APOE Antibody recognizes Apolipoprotein E (APOE), a secreted glycoprotein that plays a fundamental role in lipid transport, cholesterol homeostasis, and lipoprotein metabolism. APOE functions as a structural component of chylomicrons, very low-density lipoproteins (VLDL), and selected high-density lipoproteins (HDL), where it mediates receptor-dependent uptake and redistribution of cholesterol and triglyceride-rich lipoproteins. By interacting with members of the low-density lipoprotein receptor family, APOE facilitates lipid transport between the liver, peripheral tissues, and the central nervous system. Consequently, APOE Antibody is widely used to investigate lipid metabolism, cardiovascular biology, neurodegenerative disease, and metabolic disorders.
APOE is produced primarily by hepatocytes, which account for most circulating APOE, although substantial expression is also found in macrophages, astrocytes, microglia, and other cell types. Within the brain, APOE is the principal apolipoprotein responsible for transporting cholesterol to neurons, supporting membrane maintenance, synapse formation, and neuronal repair. Three common human isoforms, APOE2, APOE3, and APOE4, differ in their biological properties and clinical significance. In particular, the APOE4 allele is strongly associated with an increased risk of late-onset Alzheimer's disease, while APOE2 is generally associated with reduced Alzheimer's disease risk but altered lipid metabolism.
In addition to lipid transport, APOE influences numerous biological processes including immune regulation, inflammatory signaling, amyloid beta clearance, vascular integrity, and tissue repair. Dysregulated APOE expression or function has been implicated in Alzheimer's disease, atherosclerosis, hyperlipidemia, stroke, traumatic brain injury, age-related macular degeneration, and chronic inflammatory disorders. Because APOE participates in both systemic metabolism and central nervous system homeostasis, it remains one of the most extensively studied proteins in cardiovascular and neuroscience research.
NSJ Bioreagents offers highly validated APOE Antibody products for reliable detection of endogenous APOE in human and animal tissues. Clone APOE/3673 is well suited for evaluating APOE expression and localization in normal and diseased tissues. These antibodies support investigations into lipid transport, cholesterol metabolism, cardiovascular disease, neurodegeneration, and metabolic biology while providing dependable performance across a broad range of research applications.
Learn more about the role of Apolipoprotein E in lipid transport, cholesterol homeostasis and lipoprotein metabolism on our Apolipoprotein E Antibody / Lipid Transport Protein Antibody page.
Optimal dilution of the APOE antibody should be determined by the researcher.
A human recombinant Apolipoprotein E protein fragment (within amino acids 19-119) was used as the immunogen for the APOE antibody.
Aliquot the APOE antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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