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Home >> Antibodies >> Anti-IgA Antibody

Anti-IgA Antibody [clone IA761] (V2619)

  Catalog No Formulation Size Price (USD)  
Image V2619-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 429
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V2619-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 199
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V2619SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 429
SDS-PAGE analysis of purified, BSA-free IgA antibody (clone IA761) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1, kappa
Clone Name IA761
Purity Protein G affinity chromatography
UniProt P01876 , P01877
Localization Cytoplasm, cell surface and secreted
Applications Flow cytometry : 1-2ul/10^6 cells
Immunofluorescence : 0.5-1ug/ml 30 min RT
Immunohistochemistry (FFPE) : 0.5-1ug/ml 30 min RT
Limitations This Anti-IgA antibody is available for research use only.
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Description

This mAb is specific to heavy chain of IgA and shows minimal cross-reaction with heavy chains of other immunoglobulins. It is reactive with all subclasses of Alpha heavy chain. Immunoglobulins are four-chain, Y-shaped, monomeric structures comprised of two identical heavy chains and two identical light chains held together through inter-chain disulfide bonds. The chains form two domains, the Fab (antigen binding) fragment and the Fc (constant) fragment. Immunoglobulin A (IgA) is the main protein of the mucosal immune system. It is generated by B-cells in gut-associated lymphoid tissues. Daily production of IgA exceeds that of any of the other immunoglobulins. IgA exists mainly in dimers but can also exist as polymers or as monomers. Dimers and polymers contain a joining (J) chain that can be bound by the polymeric immunoglobulin receptor (pIgR) for transportation of the molecule to mucosal surfaces. The most common feature of plasmacytomas, and certain non-Hodgkin s lymphomas is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.

Application Notes

Optimal dilution of the Anti-IgA antibody should be determined by the researcher.

1. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min

Immunogen

Purified human alpha heavy chain was used as the immunogen for the Anti-IgA antibody.

Storage

Store the Anti-IgA antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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