AMPK Beta 1 Antibody AMP-Activated Protein Kinase B 1 F50060

	Catalog No	Formulation	Size	Price (USD)
	F50060-0.4ML	In 1X PBS, pH 7.4, with 0.09% sodium azide	0.4 ml	439
Formulation
	F50060-0.08ML	In 1X PBS, pH 7.4, with 0.09% sodium azide	0.08 ml	205
Formulation

AMPK Beta 1 Antibody Mouse Heart WB. Western blot analysis of mouse heart lysate demonstrates a distinct AMPK beta 1 immunoreactive band at approximately 28-30 kDa, consistent with the expected molecular weight of the protein. The observed band confirms expression of the beta 1 regulatory subunit of AMP-activated protein kinase in cardiac tissue, where AMPK plays a critical role in maintaining cellular energy homeostasis and metabolic adaptation. This AMPK Beta 1 Antibody, also called AMP-Activated Protein Kinase Beta 1 Antibody, is suitable for Western blot studies of AMPK signaling, cardiac metabolism, and cellular energy regulation.

AMPK Beta 1 Antibody Human and Mouse WB. Western blot analysis detects AMPK beta 1 in human Jurkat cell lysate (lane 1) and mouse spleen tissue lysate (lane 2). A distinct immunoreactive band is observed at approximately 30 kDa in both samples, consistent with the expected molecular weight of the beta 1 regulatory subunit of AMP-activated protein kinase. Detection in both human and mouse samples demonstrates cross-species reactivity and supports the conserved expression of this metabolic regulator. This AMPK Beta 1 Antibody, also called AMP-Activated Protein Kinase Beta 1 Antibody, is suitable for Western blot studies of AMPK signaling, cellular energy sensing, and metabolic regulation.

AMPK Beta 1 Antibody Human Hepatocarcinoma IHC. Immunohistochemical staining of FFPE human hepatocarcinoma tissue demonstrates AMPK beta 1 expression with prominent brown DAB staining in tumor cells, while nuclei are counterstained blue with hematoxylin. The predominantly cytoplasmic staining pattern is consistent with the intracellular localization of the beta 1 regulatory subunit of the AMP-activated protein kinase complex, a central regulator of cellular energy homeostasis. This AMPK Beta 1 Antibody, also called AMP-Activated Protein Kinase Beta 1 Antibody, is suitable for immunohistochemical studies of AMPK signaling, metabolic regulation, and liver cancer.

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AMPK Beta 1 Antibody Mouse Heart WB. Western blot analysis of mouse heart lysate demonstrates a distinct AMPK beta 1 immunoreactive band at approximately 28-30 kDa, consistent with the expected molecular weight of the protein. The observed band confirms expression of the beta 1 regulatory subunit of AMP-activated protein kinase in cardiac tissue, where AMPK plays a critical role in maintaining cellular energy homeostasis and metabolic adaptation. This AMPK Beta 1 Antibody, also called AMP-Activated Protein Kinase Beta 1 Antibody, is suitable for Western blot studies of AMPK signaling, cardiac metabolism, and cellular energy regulation.

AMPK Beta 1 Antibody Human and Mouse WB. Western blot analysis detects AMPK beta 1 in human Jurkat cell lysate (lane 1) and mouse spleen tissue lysate (lane 2). A distinct immunoreactive band is observed at approximately 30 kDa in both samples, consistent with the expected molecular weight of the beta 1 regulatory subunit of AMP-activated protein kinase. Detection in both human and mouse samples demonstrates cross-species reactivity and supports the conserved expression of this metabolic regulator. This AMPK Beta 1 Antibody, also called AMP-Activated Protein Kinase Beta 1 Antibody, is suitable for Western blot studies of AMPK signaling, cellular energy sensing, and metabolic regulation.

AMPK Beta 1 Antibody Human Hepatocarcinoma IHC. Immunohistochemical staining of FFPE human hepatocarcinoma tissue demonstrates AMPK beta 1 expression with prominent brown DAB staining in tumor cells, while nuclei are counterstained blue with hematoxylin. The predominantly cytoplasmic staining pattern is consistent with the intracellular localization of the beta 1 regulatory subunit of the AMP-activated protein kinase complex, a central regulator of cellular energy homeostasis. This AMPK Beta 1 Antibody, also called AMP-Activated Protein Kinase Beta 1 Antibody, is suitable for immunohistochemical studies of AMPK signaling, metabolic regulation, and liver cancer.

Availability	1-3 business days
Species Reactivity	Human, Mouse
Predicted Reactivity	Rat
Format	Purified
Host	Rabbit
Clonality	Polyclonal (rabbit origin)
Isotype	Rabbit Ig
Purity	Purified
UniProt	Q9Y478
Applications	Western Blot : 1:1000 IHC (Paraffin) : 1:50-1:100
Limitations	This AMPK Beta 1 Antibody / AMP-Activated Protein Kinase Beta 1 Antibody is available for research use only.
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Description

AMPK Beta 1 Antibody recognizes AMP-activated protein kinase beta 1 (PRKAB1), one of the regulatory subunits of the AMP-activated protein kinase (AMPK) complex that functions as the primary energy sensor in eukaryotic cells. AMPK is activated during conditions of energy stress when intracellular ATP levels decline and AMP or ADP concentrations rise, allowing cells to restore energy homeostasis by promoting ATP-generating pathways while inhibiting energy-consuming biosynthetic processes. The beta 1 subunit serves as a structural scaffold that stabilizes interactions between the catalytic alpha and regulatory gamma subunits, making it essential for assembly and activity of the functional kinase complex.

AMP-Activated Protein Kinase Beta 1 is widely expressed in tissues with high metabolic demands, including liver, skeletal muscle, heart, kidney, and brain. In addition to its scaffolding role, the beta 1 subunit contains a carbohydrate-binding module that associates with glycogen, enabling the AMPK complex to integrate information about both cellular energy status and glycogen availability. Activated AMPK regulates numerous downstream processes including glucose uptake, fatty acid oxidation, lipid synthesis, mitochondrial biogenesis, autophagy, protein synthesis, and cell growth, allowing cells to adapt efficiently to nutrient limitation and metabolic stress.

Dysregulation of AMPK signaling has been implicated in obesity, type 2 diabetes, cardiovascular disease, non-alcoholic fatty liver disease, neurodegenerative disorders, and many cancers. Because of its central role in coordinating metabolic adaptation, AMP-Activated Protein Kinase Beta 1 is frequently investigated alongside the catalytic alpha and regulatory gamma AMPK subunits to understand kinase activation, substrate selection, and downstream signaling. Interest in AMPK biology continues to expand as therapeutic strategies targeting this pathway are explored for metabolic diseases, aging, inflammation, and oncology.

An AMP-Activated Protein Kinase Beta 1 Antibody is a valuable research tool for studies of AMPK signaling, cellular energy sensing, glucose metabolism, lipid metabolism, mitochondrial function, autophagy, and metabolic disease.

For additional information about this target, see our PRKAB1 Antibody / Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 1 Antibody page.

Application Notes

Titration of the AMPK Beta 1 Antibody / AMP-Activated Protein Kinase Beta 1 Antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 4-34 from the human protein was used as the immunogen for this AMPK beta 1 antibody.

Storage

Aliquot the AMPK beta 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Alternate Names

AMPK Beta 1 antibody, AMP-Activated Protein Kinase Beta 1 antibody, PRKAB1 antibody, Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 1 antibody

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AMPK Beta 1 Antibody / AMP-Activated Protein Kinase Beta 1 Antibody (F50060)

Description

Application Notes

Immunogen

Storage

Alternate Names

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