- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Allograft inflammatory factor 1 Antibody / AIF1 / IBA1 [clone AIF1/8970R] (V5150)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V5150-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V5150-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
|
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V5150SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | AIF1/8970R |
| Purity | Protein A/G affinity |
| UniProt | P55008 |
| Localization | Cytoplasm, Cell Surface |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This Allograft inflammatory factor 1 antibody is available for research use only. |
|
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Allograft inflammatory factor 1 Antibody clone AIF1/8970R recognizes Allograft inflammatory factor 1, a cytoplasmic calcium-binding protein encoded by the AIF1 gene located on chromosome 6p21.3. Allograft inflammatory factor 1, commonly referred to as AIF1 or IBA1 in the literature, is a 17 kDa protein predominantly expressed in microglia within the central nervous system and in activated macrophages in peripheral tissues. AIF1 antibody, also known as IBA1 antibody, is widely used in studies of neuroinflammation, immune activation, and macrophage biology. This monoclonal antibody supports detection of cytoplasmic AIF1 expression in immune and neural research contexts.
AIF1 belongs to the EF-hand calcium-binding protein family and contains two EF-hand motifs that mediate calcium-dependent structural changes. Through interaction with actin and associated cytoskeletal components, Allograft inflammatory factor 1 regulates membrane ruffling, phagocytosis, and cellular motility. It is rapidly upregulated in response to inflammatory stimuli and is considered a reliable marker of activated microglia in models of neurodegenerative disease, traumatic brain injury, and inflammatory neurologic disorders.
Expression of AIF1 is largely restricted to microglia in the brain and spinal cord and to tissue macrophages in peripheral organs such as spleen, lymph node, and tonsil. Neurons and astrocytes typically show minimal baseline expression, making Allograft inflammatory factor 1 Antibody a useful tool for distinguishing resident immune cells from other neural cell types. Increased AIF1 expression has been reported in Alzheimer disease, Parkinson disease, multiple sclerosis, and glioma, reflecting microglial activation and immune cell infiltration in these conditions.
Structurally, Allograft inflammatory factor 1 is a small intracellular protein that participates in signaling pathways regulating immune cell proliferation and activation. Its calcium-dependent actin-binding properties contribute to morphological transformation of microglia from ramified to amoeboid phenotypes during inflammatory responses. Through its established role as a marker of microglial and macrophage activation, AIF1 remains central to research in neuroimmunology and inflammatory disease mechanisms.
Optimal dilution of the Allograft inflammatory factor 1 antibody should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 1-146) from the human protein was used as the immunogen for the Allograft inflammatory factor 1 antibody.
Aliquot the Allograft inflammatory factor 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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