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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Albumin (ALB) is the most abundant circulating protein in human plasma and is synthesized primarily by hepatocytes in the liver. It plays a central role in maintaining oncotic pressure, transporting endogenous and exogenous molecules, and regulating fluid balance within the circulatory system. Albumin is widely used as a marker of liver function and hepatocyte activity due to its high expression in liver tissue and secretion into the bloodstream. As a major serum protein, ALB reflects the biosynthetic capacity of hepatocytes and overall liver health.
Albumin antibody, also referred to as ALB antibody and serum albumin antibody in the literature, recognizes a highly abundant protein localized predominantly in the cytoplasm of hepatocytes and secreted into extracellular compartments. In tissue-based analysis, Albumin is characteristically observed as strong cytoplasmic staining in hepatocytes, providing clear identification of liver parenchymal cells. This staining pattern supports its use as a hepatocyte lineage marker in histological studies and tissue characterization. This antibody is part of a collection of Human Protein Microarray validated antibodies that have been screened for specificity across thousands of proteins.
This Albumin Antibody / Liver Function and Serum Protein Marker Antibody (clone ALB/2141) is uniquely positioned for studies of liver biology and hepatocyte-associated processes. In hepatocellular carcinoma and other liver-derived tissues, Albumin expression is retained in tumor hepatocytes, allowing distinction between hepatocyte-derived tumor cells and non-hepatic components within the tissue microenvironment. This makes Albumin a valuable marker for identifying hepatic origin and assessing cellular differentiation in liver tissue samples.
In western blot analysis, Albumin is typically detected as a prominent band corresponding to its expected molecular weight, particularly in liver tissue lysates where expression is highest. In immunohistochemistry, strong cytoplasmic staining highlights hepatocytes and hepatocyte-derived tumor cells, while surrounding stromal and non-hepatic tissues show minimal signal. These consistent expression patterns support reliable detection across multiple experimental approaches.
Microarray validation of clone ALB/2141 supports its specificity for Albumin, providing confidence in target recognition across a broad range of proteins. As a mouse monoclonal antibody, clone ALB/2141 offers reproducible performance for detecting Albumin in research applications. An Albumin antibody is suitable for detecting ALB expression in studies of liver function, hepatocyte biology, and serum protein dynamics.
This antibody is part of a broader antibody panel offered by NSJ Bioreagents.
The optimal dilution of the Albumin Antibody / Liver Function and Serum Protein Marker Antibody for each application should be determined by the researcher.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Full length recombinant human protein was used as the immunogen for this human Albumin antibody.
Store the human Albumin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Albumin antibody, ALB antibody, Serum albumin antibody, Human serum albumin antibody, HSA antibody
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