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Home >> Antibodies >> ABCB11 Antibody

ABCB11 Antibody (F49436)

  Catalog No Formulation Size Price (USD)  
Image F49436-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 329
Image
F49436-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 135
IHC analysis of FFPE human hepatocarcinoma tissue stained with the ABCB11 antibody
ABCB11 antibody western blot analysis with mouse liver tissue lysate
Availability 1-3 business days
Species Reactivity Human, Mouse
Format Purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Purified
UniProt O95342
Applications Western blot : 1:1000
IHC (Paraffin) : 1:50-1:100
Limitations This ABCB11 antibody is available for research use only.
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Description

ABCB11 is involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. It is expressed predominatly, if not exclusively, in the liver, where it is further localized to the canilicular microvilli and to subcanilicular vesicles fo the hepatocytes. Structurally, ABCB11 is a multifunctional polypeptide with two homologus halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain. Defects in ABCB11 are the cause of progressive familial intrahepatic cholestasis 2 (PFIC2). PFIC2 is an inherited liver disease of childhood which is characterized by cholestasis and normal serum gamma-glutamyltransferase activity. Defects in ABCB11 are also found in cases of chronic intrahepatic cholestasis without obvious familial history of chronic liver disease.

Application Notes

Titration of the ABCB11 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 1038-1067 from the human protein was used as the immunogen for this ABCB11 antibody.

Storage

Aliquot the ABCB11 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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