KRT9 Antibody / Keratin 9 Antibody

KRT9 Antibody Overview

KRT9 Antibody detects keratin 9, an intermediate filament protein belonging to the type I keratin family. KRT9 is predominantly expressed in the suprabasal layers of palmoplantar epidermis, where it contributes to mechanical stability and resilience of thick skin. Mutations in KRT9 are causative for epidermolytic palmoplantar keratoderma (EPPK), a rare hereditary disorder characterized by thickened, blister-prone skin on palms and soles.

The KRT9 Antibody provides researchers with a specific and reliable tool for detecting this keratin in tissue sections, protein lysates, and cultured cells. Because of its restricted expression pattern, KRT9 serves as a powerful marker for palmoplantar epithelium and related skin disorders. By enabling precise detection of keratin 9, the KRT9 Antibody supports both fundamental biology and translational medicine.

Why Choose KRT9 Antibodies from NSJ Bioreagents?

NSJ Bioreagents offers KRT9 Antibodies validated for immunohistochemistry, immunofluorescence, western blotting, and ELISA. Each KRT9 Antibody undergoes rigorous quality testing to confirm specificity for keratin 9 and minimize cross-reactivity with other keratin isoforms.

By choosing a KRT9 Antibody from NSJ Bioreagents, researchers gain reagents optimized for reproducibility. Our antibodies provide strong staining in palmoplantar skin, reliable detection in protein assays, and consistent performance in cell models. With comprehensive datasheets, positive control guidance, and detailed application protocols, NSJ Bioreagents ensures that Keratin 9 Antibody products meet the needs of both discovery and clinical research.

Applications of KRT9 Antibodies

The KRT9 Antibody has broad applications in dermatology, pathology, and translational medicine.

1) Skin Biology and Differentiation

• KRT9 Antibodies identify palmoplantar epidermis in tissue studies.

• The KRT9 Antibody is used to distinguish thick skin from other epithelial tissues.

• Researchers apply Keratin 9 Antibody tools to study keratinocyte differentiation pathways.

2) Keratin Disorders and Genetic Disease

• Mutations in KRT9 cause EPPK, making KRT9 Antibodies essential for studying disease pathology.

• The KRT9 Antibody is applied to confirm loss-of-function or gain-of-function variants in patient samples.

• Researchers use Keratin 9 Antibody reagents in genetic models to understand disease mechanisms.

3) Dermatopathology and Clinical Diagnostics

• The KRT9 Antibody supports differential diagnosis of keratinizing disorders.

• KRT9 Antibodies are applied in biopsy analysis to confirm palmoplantar origin.

• The KRT9 Antibody helps assess disease progression in hereditary keratodermas.

4) Regenerative and Stem Cell Research

• KRT9 Antibodies validate differentiation of stem cells into keratinocytes resembling palmoplantar epithelium.

• The KRT9 Antibody is used in regenerative models to confirm correct keratin expression.

5) Oncology and Cancer Biology

• KRT9 Antibodies are applied to investigate keratin expression patterns in rare palmoplantar carcinomas.

• The KRT9 Antibody helps distinguish keratin subtypes in tumor classification studies.

6) Translational and Drug Discovery

• KRT9 Antibodies support therapeutic development for keratinopathies.

• The KRT9 Antibody validates gene therapy and small molecule approaches aimed at correcting keratin mutations.

• Keratin 9 Antibody reagents are applied to test novel treatments in preclinical models.

Why Are KRT9 Antibodies Important?

Keratin 9 plays a highly specific role in palmoplantar skin integrity. The KRT9 Antibody enables precise study of this keratin, while Keratin 9 Antibody reagents more broadly support research in dermatology, genetics, and regenerative medicine.

In basic biology, KRT9 Antibodies clarify differentiation programs of specialized epidermis. In pathology, the KRT9 Antibody distinguishes palmoplantar tissues and keratinization disorders. In genetic medicine, Keratin 9 Antibody products help characterize disease-causing mutations and their effects.

Clinically, KRT9 mutations provide both diagnostic and therapeutic targets in hereditary palmoplantar keratoderma. By enabling accurate detection, the KRT9 Antibody connects molecular understanding with clinical outcomes, supporting progress in dermatology and translational research.

Conclusion

Keratin 9 is essential for the structural stability of palmoplantar skin, and its mutations cause debilitating skin disorders. The KRT9 Antibody equips researchers and clinicians with a specific, reliable tool to study keratin 9 expression, while Keratin 9 Antibody reagents more broadly support discoveries in skin biology, pathology, and therapy development. By linking molecular insights with clinical applications, these antibodies remain indispensable for advancing dermatology and improving patient outcomes.