Cytokeratin 12 Antibody / CK12 Antibody

Cytokeratin 12 Antibody Overview

Cytokeratin 12 Antibody reagents target keratin 12 (KRT12), a type I intermediate filament protein expressed almost exclusively in the corneal epithelium. KRT12 pairs with keratin 3 to provide mechanical stability, protect against shear stress, and maintain the transparency of the cornea. Its highly restricted distribution makes it one of the most specific markers for corneal epithelial identity.

Mutations in KRT12 are associated with Meesmann corneal dystrophy, a hereditary epithelial disorder characterized by fragility, recurrent erosions, and microcyst formation in the cornea. Because of its unique expression and clinical significance, the Cytokeratin 12 Antibody is a critical tool in ocular biology, ophthalmic pathology, and regenerative medicine. The CK12 Antibody also supports broader applications in developmental biology and translational ophthalmology.

Why Choose Cytokeratin 12 Antibodies from NSJ Bioreagents?

NSJ Bioreagents provides Cytokeratin 12 Antibodies validated for immunohistochemistry, immunofluorescence, western blotting, and ELISA. Each Cytokeratin 12 Antibody is rigorously tested to ensure specificity, reproducibility, and minimal background in ocular tissues.

By selecting Cytokeratin 12 Antibodies from NSJ Bioreagents, researchers gain reagents optimized for clarity and reliability. Our antibodies provide strong corneal staining, reproducible detection in protein lysates, and consistent performance across multiple experimental platforms. Detailed datasheets, suggested positive controls, and validated protocols further ensure reproducibility in both discovery and diagnostic settings.

Applications of Cytokeratin 12 Antibodies

The Cytokeratin 12 Antibody supports specialized but highly impactful applications in eye research and diagnostics.

1) Corneal Biology and Ocular Research

• Cytokeratin 12 Antibodies confirm epithelial lineage in the cornea.

• The Cytokeratin 12 Antibody highlights differentiation of corneal epithelial cells.

• CK12 Antibody reagents help map tissue-specific keratin expression.

2) Genetic Eye Disorders

• Cytokeratin 12 Antibodies identify KRT12 mutations linked to Meesmann corneal dystrophy.

• The Cytokeratin 12 Antibody supports research into genetic mechanisms of corneal fragility.

• CK12 Antibody reagents validate biomarkers for hereditary ocular disorders.

3) Pathology and Diagnostics

• Cytokeratin 12 Antibodies distinguish corneal epithelium from conjunctival or other ocular tissues.

• The Cytokeratin 12 Antibody supports pathology panels in ophthalmology.

• CK12 Antibody reagents enhance diagnostic accuracy in ocular biopsies.

4) Regenerative and Stem Cell Biology

• Cytokeratin 12 Antibodies validate corneal epithelial differentiation in stem cell-derived organoids.

• The Cytokeratin 12 Antibody confirms lineage fidelity in regenerative models.

• CK12 Antibody reagents support translational ophthalmology research.

5) Inflammation and Infectious Disease

• Cytokeratin 12 Antibodies highlight corneal epithelial responses to infection and injury.

• The Cytokeratin 12 Antibody supports studies into ocular inflammation and pathogen–host interactions.

6) Translational and Clinical Research

• Cytokeratin 12 Antibodies are applied in biomarker-driven clinical studies.

• The Cytokeratin 12 Antibody contributes to patient monitoring in precision ophthalmology.

• CK12 Antibody reagents provide reproducibility in translational workflows.

Why Are Cytokeratin 12 Antibodies Important?

KRT12 is a defining marker of corneal epithelial identity and integrity. The Cytokeratin 12 Antibody equips scientists with precise tools to detect and study this protein, while the CK12 Antibody extends its applications across ocular pathology, regenerative research, and clinical diagnostics.

In basic corneal biology, Cytokeratin 12 Antibodies validate epithelial lineage and differentiation. In genetic eye disorders, the Cytokeratin 12 Antibody identifies pathogenic KRT12 mutations. In clinical pathology, CK12 Antibody reagents provide diagnostic clarity in ocular biopsies.

Clinically, KRT12 remains one of the most specific and reliable biomarkers for corneal epithelium. Cytokeratin 12 Antibodies ensure reproducibility and reliability, bridging laboratory science with translational ophthalmology and patient care.

Conclusion

Cytokeratin 12 is a tissue-specific corneal keratin with essential roles in epithelial structure, disease, and diagnostics. The Cytokeratin 12 Antibody equips researchers and clinicians with validated reagents for studying KRT12 in ocular biology, pathology, and regenerative medicine, while the CK12 Antibody provides complementary support in translational applications. By ensuring specificity and reproducibility, these antibodies remain indispensable for advancing ophthalmic research and improving clinical outcomes.