Blood Group Antigen H Antibody / ABO Antibody

Blood Group Antigen H Antibody Overview

Blood Group Antigen H Antibody reagents target antigen H, the essential precursor for the ABO blood group system. Antigen H is a fucosylated oligosaccharide present on the surface of red blood cells and other tissues. In individuals with normal glycosyltransferase activity, antigen H is enzymatically modified to form the A or B antigens. In blood group O, antigen H remains unmodified, serving as the defining feature of the O phenotype.

Defects in antigen H expression are most notable in the rare Bombay phenotype (Oh), where mutations in FUT1 prevent its synthesis. This condition results in the absence of H, A, and B antigens, complicating blood transfusion compatibility. Because of its central role in transfusion medicine and immunohematology, the Blood Group Antigen H Antibody is an important tool for research into blood group biochemistry, immune recognition, and clinical diagnostics. The ABO Antibody category provides broader tools for studying ABO antigen diversity and transfusion compatibility.

Why Choose Blood Group Antigen H Antibodies from NSJ Bioreagents?

NSJ Bioreagents provides Blood Group Antigen H Antibodies validated for immunohistochemistry, western blotting, flow cytometry, immunofluorescence, and ELISA. Each Blood Group Antigen H Antibody undergoes rigorous quality testing to ensure specificity, reproducibility, and reliable performance across immunohematology applications.

By choosing Blood Group Antigen H Antibodies from NSJ Bioreagents, researchers gain reagents optimized for clarity and consistency. Our antibodies provide robust staining of red blood cell antigens, reproducible protein detection in lysates, and dependable results across both discovery and diagnostic workflows. Detailed datasheets, suggested controls, and validated protocols further ensure reproducibility.

Applications of Blood Group Antigen H Antibodies

The Blood Group Antigen H Antibody supports diverse applications in hematology, immunology, and clinical science.

1) Transfusion Medicine

• Blood Group Antigen H Antibodies confirm expression of antigen H on red blood cells.

• The Blood Group Antigen H Antibody supports compatibility testing and rare blood typing.

• ABO Antibody reagents provide complementary tools for transfusion workflows.

2) Hematology and Immunohematology

• Blood Group Antigen H Antibodies highlight glycosyltransferase activity.

• The Blood Group Antigen H Antibody supports studies of red cell antigen biosynthesis.

• ABO Antibody reagents clarify immune recognition in hematology research.

3) Rare Blood Group Phenotypes

• Blood Group Antigen H Antibodies identify the Bombay phenotype.

• The Blood Group Antigen H Antibody supports genetic and biochemical studies of FUT1 mutations.

• ABO Antibody reagents validate rare transfusion compatibility panels.

4) Developmental and Stem Cell Biology

• Blood Group Antigen H Antibodies detect expression during hematopoietic differentiation.

• The Blood Group Antigen H Antibody supports stem cell and organoid models.

• ABO Antibody reagents contribute to regenerative medicine studies.

5) Infectious Disease Research

• Blood Group Antigen H Antibodies clarify host–pathogen interactions involving blood group antigens.

• The Blood Group Antigen H Antibody supports studies into susceptibility to viral and bacterial infections.

• ABO Antibody reagents contribute to epidemiological and translational research.

6) Translational and Clinical Research

• Blood Group Antigen H Antibodies are integrated into biomarker-driven transfusion studies.

• The Blood Group Antigen H Antibody supports precision diagnostics and patient stratification.

• ABO Antibody reagents ensure reproducibility in translational medicine.

Why Are Blood Group Antigen H Antibodies Important?

Antigen H is the foundation of the ABO system, the most clinically significant blood group system in transfusion medicine. The Blood Group Antigen H Antibody provides scientists and clinicians with validated reagents to study antigen biosynthesis, blood compatibility, and rare phenotypes. The ABO Antibody complements these studies by providing tools to investigate broader ABO antigen variation.

In hematology, Blood Group Antigen H Antibodies confirm antigen expression and biosynthetic pathways. In transfusion medicine, the Blood Group Antigen H Antibody is essential for compatibility testing, particularly in rare phenotypes. In infectious disease research, ABO Antibody reagents highlight links between blood group antigens and pathogen susceptibility.

Clinically, antigen H detection remains essential for ensuring safe transfusion practices and understanding genetic variants like the Bombay phenotype. Reliable antibodies bridge laboratory insights with patient safety.

Conclusion

Blood group antigen H is the biochemical foundation of the ABO system, central to transfusion medicine and immunohematology. The Blood Group Antigen H Antibody provides validated reagents for studying antigen expression, compatibility, and rare phenotypes, while the ABO Antibody supports complementary applications in diagnostics and translational medicine. By ensuring specificity and reproducibility, these antibodies remain indispensable for advancing blood group biology and improving patient outcomes.