Angiotensin I Converting Enzyme Antibody / ACE Antibody

Angiotensin I Converting Enzyme Antibody Overview

Angiotensin I Converting Enzyme Antibody reagents target one of the most critical enzymes in cardiovascular biology. Angiotensin-converting enzyme (ACE) is a zinc metallopeptidase that plays a central role in the renin–angiotensin system (RAS) by converting angiotensin I into angiotensin II, a potent vasoconstrictor that regulates blood pressure and fluid balance. In addition, ACE degrades bradykinin, a vasodilator, further shifting the balance toward vascular tone and systemic regulation.

ACE is expressed in multiple tissues, with the highest concentrations in vascular endothelial cells, kidneys, lungs, and reproductive organs. Dysregulation of ACE expression or activity has been linked to hypertension, heart failure, renal disease, pulmonary hypertension, and inflammatory conditions. Because ACE is also a therapeutic target of widely prescribed ACE inhibitors, the Angiotensin I Converting Enzyme Antibody is indispensable for basic research, clinical diagnostics, and translational pharmacology. The ACE Antibody provides a complementary reagent for supporting studies across assay formats and biological systems.

Why Choose Angiotensin I Converting Enzyme Antibodies from NSJ Bioreagents?

NSJ Bioreagents offers Angiotensin I Converting Enzyme Antibodies validated for immunohistochemistry (IHC), western blotting (WB), immunofluorescence (IF), flow cytometry (FACS), and ELISA. Each antibody undergoes stringent validation to guarantee specificity, reproducibility, and compatibility across diverse applications.

Key advantages include:

• Broad Application Range: Validated for tissues, lysates, and cell-based assays.

• Batch Consistency: Ensures reproducibility across long-term projects.

• Technical Support: Detailed datasheets and recommended protocols.

• Pathway Coverage: Directly targets one of the most clinically significant enzymes in cardiovascular research.

• Translational Value: Suitable for research, biomarker discovery, and clinical diagnostics.

By choosing NSJ Bioreagents, scientists can rely on the Angiotensin I Converting Enzyme Antibody to deliver clarity and reproducibility across all experimental platforms.

Applications of Angiotensin I Converting Enzyme Antibodies

The Angiotensin I Converting Enzyme Antibody supports a wide spectrum of research areas in cardiovascular, renal, pulmonary, and translational medicine.

1) Cardiovascular Biology and Hypertension

• Detect ACE expression in endothelial cells, myocardium, and arterial walls.

• Support studies of angiotensin II generation and blood pressure regulation.

• Validate biomarkers for hypertensive disease progression.

• Provide translational tools for cardiovascular drug discovery.

2) Heart Failure and Cardiac Remodeling

• Angiotensin I Converting Enzyme Antibody detects increased ACE expression in failing myocardium.

• Supports research into fibrosis, hypertrophy, and maladaptive remodeling.

• Provides translational biomarkers for therapeutic efficacy of ACE inhibitors.

• Extends into clinical research linking ACE to long-term cardiac outcomes.

3) Renal Physiology and Fluid Balance

• Angiotensin I Converting Enzyme Antibody detects expression in renal proximal tubules.

• Supports studies of sodium handling and water reabsorption.

• Provides biomarkers for diabetic nephropathy and chronic kidney disease.

• Extends into translational nephrology and patient stratification studies.

4) Pulmonary Biology

• Detect ACE in pulmonary endothelial cells using Angiotensin I Converting Enzyme Antibody reagents.

• Support studies of acute respiratory distress syndrome (ARDS) and pulmonary hypertension.

• Clarify ACE’s role in bradykinin metabolism and lung injury.

• Provide translational biomarkers for respiratory disease pipelines.

5) Inflammation and Immunology

• Angiotensin I Converting Enzyme Antibody detects altered expression in immune cells.

• Supports studies of ACE activity in macrophages and granulocytes.

• Links ACE dysregulation to systemic inflammation and autoimmune conditions.

• Provides translational markers for cytokine and immune regulation.

6) Neurology and Brain Research

• Detect endothelial expression in the brain using Angiotensin I Converting Enzyme Antibody reagents.

• Support studies of vascular dementia and Alzheimer’s disease.

• Clarify ACE’s potential role in amyloid-β metabolism.

• Provide translational biomarkers for neurovascular disease research.

7) Pharmacology and Drug Discovery

• Angiotensin I Converting Enzyme Antibody validates ACE as a therapeutic target.

• Supports research into ACE inhibitors and next-generation modulators.

• Provides translational biomarkers for assessing therapeutic efficacy.

• Extends into pharmacogenomics, linking ACE expression to patient response.

8) Clinical and Diagnostic Research

• Detect ACE in biopsies and clinical samples with Angiotensin I Converting Enzyme Antibody.

• Support diagnostics for sarcoidosis, where serum ACE levels are elevated.

• Provide translational biomarkers for hypertension and kidney disease.

• Ensure reproducibility in clinical and biomarker-driven pipelines.

Why Are Angiotensin I Converting Enzyme Antibodies Important?

ACE is a cornerstone of cardiovascular physiology, influencing blood pressure, vascular tone, and systemic fluid balance. The Angiotensin I Converting Enzyme Antibody equips researchers with validated reagents for detecting ACE in tissues, monitoring expression changes in disease, and validating therapeutic interventions.

In cardiology, it clarifies ACE’s role in hypertension, heart failure, and remodeling. In nephrology, it supports studies of kidney function and chronic disease. In pulmonary research, it reveals ACE’s impact on vascular regulation and bradykinin metabolism. In neurology, it extends applications into vascular dementia and Alzheimer’s disease.

Clinically, ACE is one of the most well-validated therapeutic targets in medicine. Reliable ACE Antibody reagents complement the primary Angiotensin I Converting Enzyme Antibody by ensuring reproducibility across research and clinical workflows.

Conclusion

Angiotensin-converting enzyme is central to cardiovascular, renal, pulmonary, and neurological health. The Angiotensin I Converting Enzyme Antibody provides validated tools for studying ACE expression, blood pressure regulation, and therapeutic intervention, while the ACE Antibody serves as a complementary reagent across multiple platforms. By ensuring specificity, reproducibility, and assay versatility, these antibodies remain indispensable for advancing cardiovascular research and improving patient care.