ACE Antibody / Angiotensin I Converting Enzyme Antibody

ACE Antibody Overview

ACE Antibody reagents target angiotensin I converting enzyme (ACE), a zinc metallopeptidase central to the renin–angiotensin–aldosterone system (RAAS). ACE cleaves angiotensin I into angiotensin II, a potent vasoconstrictor that regulates blood pressure, vascular tone, and fluid balance.

ACE is expressed on the surface of endothelial cells, particularly in the lungs, kidneys, and vascular system, as well as in circulating plasma. Beyond blood pressure regulation, ACE modulates inflammatory responses, renal function, and vascular remodeling. Dysregulated ACE activity is strongly associated with hypertension, heart failure, kidney disease, and atherosclerosis.

Because of its central role in cardiovascular homeostasis, the ACE Antibody is indispensable for vascular biology, hypertension studies, renal disease research, and translational medicine. The Angiotensin I Converting Enzyme Antibody complements these applications with reproducible detection across experimental systems.

Why Choose ACE Antibodies from NSJ Bioreagents?

NSJ Bioreagents provides ACE Antibodies validated for immunohistochemistry (IHC), western blotting (WB), immunofluorescence (IF), flow cytometry (FACS), and ELISA. Each antibody is rigorously tested for specificity, reproducibility, and assay compatibility.

Advantages include:

• Vascular Relevance: Detects ACE in endothelial, renal, and cardiac tissues.

• Assay Flexibility: Works across multiple detection platforms.

• Batch Consistency: Reliable performance across long-term projects.

• Detailed Documentation: Datasheets with validation data and protocols.

• Translational Utility: Suitable for biomarker-driven and clinical research.

By choosing NSJ Bioreagents, researchers ensure their ACE Antibody provides clarity, reliability, and reproducibility across vascular and metabolic studies.

Applications of ACE Antibodies

The ACE Antibody supports broad applications in cardiovascular biology, renal research, and translational medicine.

1) Hypertension and Vascular Biology

• Detect ACE expression in vascular endothelium.

• Support studies of angiotensin II generation and blood pressure regulation.

• Provide biomarkers for essential and secondary hypertension.

• Extend into translational cardiovascular pipelines.

2) Heart Failure and Cardiac Remodeling

• ACE Antibody detects enzyme activity in failing myocardium.

• Supports research into hypertrophy, remodeling, and fibrosis.

• Provides biomarkers for ACE inhibitors and therapeutic response.

• Extends into translational cardiology.

3) Renal Disease and Fluid Balance

• Detect ACE expression in renal proximal tubules.

• Support studies of sodium retention, fluid balance, and diabetic nephropathy.

• Provide biomarkers for chronic kidney disease progression.

• Extend into nephrology pipelines.

4) Atherosclerosis and Vascular Inflammation

• ACE Antibody detects expression in vascular lesions.

• Supports research into endothelial dysfunction and vascular remodeling.

• Provides biomarkers for inflammatory vascular disease.

• Extends into translational atherosclerosis research.

5) Inflammation and Immunology

• Detect ACE modulation in immune cells such as macrophages.

• Support studies linking RAAS to inflammatory signaling.

• Provide biomarkers for chronic inflammatory conditions.

• Extend into translational immunology.

6) Pharmacology and Therapeutics

• ACE is a therapeutic target for ACE inhibitors widely used in hypertension and heart failure.

• ACE Antibody supports validation of drug mechanisms.

• Provides biomarkers for clinical efficacy and drug response.

• Extends into pharmaceutical research pipelines.

7) Translational and Clinical Research

• ACE Antibody supports biomarker studies in hypertension and cardiovascular disease.

• Provides reproducibility in clinical assay development.

• Links basic research to translational outcomes in vascular health.

• Ensures diagnostic reliability across clinical pipelines.

Why Are ACE Antibodies Important?

ACE sits at the heart of vascular regulation, converting angiotensin I to angiotensin II and modulating aldosterone release. The ACE Antibody equips researchers to study this enzyme in vascular, renal, and cardiac biology.

In cardiology, it clarifies ACE’s roles in hypertension and heart failure. In nephrology, it highlights ACE’s impact on renal function and disease progression. In vascular biology, it supports studies of atherosclerosis and remodeling. In immunology, it reveals links between RAAS and inflammation.

Clinically, ACE is both a biomarker and therapeutic target. ACE inhibitors revolutionized the management of hypertension, heart failure, and kidney disease. Reliable Angiotensin I Converting Enzyme Antibody reagents ensure reproducibility, bridging laboratory research with diagnostic and therapeutic pipelines.

Conclusion

ACE is a zinc metallopeptidase critical for blood pressure regulation, vascular health, and renal function. The ACE Antibody provides validated tools for cardiovascular, renal, and translational research, while the Angiotensin I Converting Enzyme Antibody complements these applications across multiple assays. By ensuring specificity, reproducibility, and assay versatility, these antibodies remain indispensable for advancing vascular biology and clinical medicine.