14-3-3 epsilon Antibody / YWHAE Antibody

14-3-3 epsilon Antibody Overview

14-3-3 epsilon Antibody reagents target the YWHAE gene product, a member of the highly conserved 14-3-3 protein family. These proteins act as molecular scaffolds, binding phosphoserine- and phosphothreonine-containing proteins to regulate diverse cellular processes. YWHAE participates in pathways controlling signal transduction, cell cycle progression, apoptosis, neuronal development, and stress responses.

Among the 14-3-3 isoforms, epsilon is expressed broadly across tissues, with enriched roles in brain and central nervous system development. It interacts with proteins involved in cytoskeletal organization, vesicle trafficking, and kinase signaling. Dysregulation of YWHAE has been linked to neurological disorders, psychiatric disease, and tumor progression.

Because of these wide-ranging functions, the 14-3-3 epsilon Antibody is a critical tool for neuroscience, oncology, developmental biology, and translational research. The YWHAE Antibody ensures reproducible detection across platforms, supporting studies from basic biology to clinical pipelines.

Why Choose 14-3-3 epsilon Antibodies from NSJ Bioreagents?

NSJ Bioreagents provides 14-3-3 epsilon Antibodies validated for immunohistochemistry (IHC), western blotting (WB), immunofluorescence (IF), flow cytometry (FACS), and ELISA. Each antibody undergoes rigorous quality control for specificity, reproducibility, and assay reliability.

Benefits include:

• Neuroscience Relevance: Detects protein critical for brain development and signaling.

• Assay Versatility: Works across tissues, cultured cells, and biochemical assays.

• Batch Consistency: Ensures reproducibility across long-term studies.

• Comprehensive Documentation: Datasheets with protocols, validation data, and suggested controls.

• Translational Utility: Suitable for biomarker-driven and therapeutic research.

By selecting NSJ Bioreagents, scientists gain reliable tools for advancing research with the 14-3-3 epsilon Antibody.

Applications of 14-3-3 epsilon Antibodies

The 14-3-3 epsilon Antibody supports diverse applications spanning cell signaling, neuroscience, oncology, and translational medicine.

1) Signal Transduction and Kinase Pathways

• Detect interactions of YWHAE with kinases and phosphorylated substrates.

• Support studies of MAPK, PI3K/AKT, and stress response pathways.

• Provide biomarkers for cellular adaptation to environmental stimuli.

• Extend into translational signaling research.

2) Cell Cycle and Apoptosis

• 14-3-3 epsilon Antibody detects roles in checkpoint control and apoptosis regulation.

• Supports research into DNA damage response and tumor suppression.

• Provides biomarkers for proliferative disorders.

• Extends into translational oncology pipelines.

3) Neuroscience and Brain Development

• Detect YWHAE expression in neurons, glia, and synaptic regions.

• Support studies of brain morphogenesis and cortical development.

• Provide biomarkers for psychiatric and neurodevelopmental disorders.

• Extend into translational neuroscience.

4) Neurodegenerative and Psychiatric Disease

• Altered 14-3-3 epsilon levels observed in schizophrenia, epilepsy, and Alzheimer’s disease.

• Antibodies support biomarker discovery in cerebrospinal fluid.

• Provide reproducibility in translational psychiatric research.

• Extend into therapeutic development pipelines.

5) Cancer and Tumor Biology

• Detect altered YWHAE expression in breast, ovarian, and brain tumors.

• Support studies of oncogenic signaling and metastasis.

• Provide biomarkers for cancer prognosis and therapy response.

• Extend into translational oncology.

6) Cytoskeletal Organization and Vesicle Trafficking

• 14-3-3 epsilon Antibody detects interactions with cytoskeletal proteins.

• Supports research into intracellular trafficking and polarity.

• Provides biomarkers for cell migration and invasion.

• Extends into translational cell biology pipelines.

7) Developmental Biology

• Detect YWHAE expression during embryogenesis.

• Support studies of morphogenesis and tissue specification.

• Provide biomarkers for developmental syndromes.

• Extend into translational developmental biology.

8) Translational and Clinical Research

• 14-3-3 epsilon Antibody supports biomarker studies in neurological and oncological disease.

• Provides reproducibility for diagnostic pipelines.

• Ensures assay consistency in translational research.

• Bridges laboratory discovery with clinical outcomes.

Why Are 14-3-3 epsilon Antibodies Important?

YWHAE is a multifunctional signaling hub that integrates phosphorylation events to regulate survival, growth, and development. The 14-3-3 epsilon Antibody equips researchers with validated reagents to study these functions in both health and disease.

In neuroscience, it clarifies how YWHAE shapes brain development and psychiatric risk. In oncology, it reveals roles in tumor signaling and progression. In cell biology, it defines cytoskeletal and trafficking regulation. In clinical research, the YWHAE Antibody supports biomarker-driven diagnostics for neurological and oncological disorders.

Clinically, 14-3-3 proteins are emerging biomarkers in cerebrospinal fluid for neurodegenerative disease, while dysregulated YWHAE is a candidate marker in cancer prognosis. Reliable 14-3-3 epsilon Antibody reagents ensure reproducibility across research, translational, and clinical studies.

Conclusion

14-3-3 epsilon is a phosphoserine-binding scaffold protein essential for signal transduction, brain development, and cancer biology. The 14-3-3 epsilon Antibody provides validated tools for neuroscience, oncology, and translational studies, while the YWHAE Antibody complements these applications across multiple assays. By ensuring specificity, reproducibility, and assay versatility, these antibodies remain indispensable for advancing fundamental and clinical research.