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Home >> Antibodies >> Tlr4 Antibody / Toll like receptor 4

Tlr4 Antibody / Toll like receptor 4 (RQ7411)

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  Catalog No Formulation Size Price (USD)  
Image RQ7411 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of mouse RAW264.7 cell lysate with Tlr4 antibody. Expected molecular weight: 96-135 kDa depending on glycosylation level.
Western blot testing of mouse RAW264.7 cell lysate with Tlr4 antibody. Expected molecular weight: 96-135 kDa depending on glycosylation level.
Availability 1-3 business days
Species Reactivity Mouse
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity purified
Buffer Lyophilized from 1X PBS with 2% Trehalose
UniProt Q9QUK6
Applications Western blot : 0.5-1ug/ml
Direct ELISA : 0.1-0.5ug/ml
Limitations This Tlr4 antibody is available for research use only.
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Description

Toll-like receptor 4 is a protein that in humans is encoded by the TLR4 gene. This gene belongs to the evolutionarily-conserved Toll-like receptor family, whose members are type-1 transmembrane proteins that are involved in innate immunity. Toll-like receptors are characterized by an extracellular leucine-rich repeat domain that functions in ligand recognition and an intracellular toll/interleukin-1 receptor-like domain that is crucial for signal transduction. The receptor encoded by this gene mediates the innate immune response to bacterial lipopolysaccharide, a major component of the outer membrane of Gram-negative bacteria, through synthesis of pro-inflammatory cytokines and chemokines. In addition, this protein can recognize other pathogens from Gram-negative and Gram-positive bacteria as well as viral components. Mice deficient in this gene display a number of immune response-related phenotypes including hyporesponsiveness to bacterial lipopolysaccharide and increased levels of respiratory syncytial virus compared to controls.

Application Notes

Optimal dilution of the Tlr4 antibody should be determined by the researcher.

Immunogen

E. coli-derived recombinant mouse protein (amino acids N26-E827) was used as the immunogen for the Tlr4 antibody.

Storage

After reconstitution, the Tlr4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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