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- Tel: 858.663.9055
- Email: info@nsjbio.com
The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines.
Titration of the SOCS6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 40-69 from the human protein was used as the immunogen for this SOCS6 antibody.
Aliquot the SOCS6 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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