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  • Tel: 858.663.9055
  • Email: info@nsjbio.com
Home >> Antibodies >> CYLD Antibody

CYLD Antibody (N1164)

  Catalog No Formulation Size Price (USD)  
N1164-100UG 0.5 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 275

N1164-25UG 0.5 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 25 ug 129
Western blot testing of human samples with CYLD antibody at 2ug/ml. Predicted molecular weight ~107kDa.
Species Reactivity Human, Mouse
Format Purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Protein A affinity chromatography
Buffer 1X PBS, pH 7.4
Gene ID 1540
Applications Western blot : 2-5ug/ml
Limitations This CYLD antibody is available for research use only.

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Description

CYLD is involved in multiple physiological processes including immune response, osteoclastogenesis and spermatogenesis. It is a tumor suppressor via its negative regulation of NF-kB activation. CYLD is a deubiquitinase, removing ubiquitin chains from tumor-necrosis factor receptor-associated factor 2 (TRAF2) and thereby preventing its activation of IkB, a regulator of NF-kB. NF-kB remains sequestered in the cytoplasm, unable to translocate to the nucleus and initiate cell survival and oncogenetic signaling.

Application Notes

Provided assay concentrations are suggestions only, CYLD antibody titration may be required for optimal results.

Immunogen

A recombinant protein fragment from the N-termiinal region of human CYLD was used as the immunogen for this antibody.

Storage

Aliquot the CYLD antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Alternate Names

Cylindromatosis, BRSS, CDMT antibody

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