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- Tel: 858.663.9055
- Email: info@nsjbio.com
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The alpha-beta heterodimeric T-cell antigen receptor binds antigen in association with major histocompatibility complex proteins on host cell surfaces. These 2 disulfide-linked glycoproteins, TCRA and TCRB are associated on T-cell surfaces with a complex of proteins called CD3(formerly T3). Human CD3 consists of at least 4 proteins: gamma, delta, epsilon, and zeta. The CD3-gamma/CD3-delta gene pair is within 300 kb of the CD3-epsilon gene and therefore these genes form a tightly linked cluster on 11q23. The clustering may be significant in terms of their simultaneous activations during T-cell development.
The stated application concentrations are suggested starting amounts. Titration of the CD3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Human thymocytes followed by Sezary T cells was used as the immunogen for this CD3 antibody.
After reconstitution, the CD3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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