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- Tel: 858.663.9055
- Email: info@nsjbio.com
ZFYVE28 belongs to the lst-2 family. It contains 1 FYVE-type zinc finger. The FYVE-type zinc finger mediates the interaction with phosphatidylinositol 3-phosphate (PI3P) and localization to early endosome membranes when not mono-ubiquitinated at Lys-87. Mono-ubiquitination at Lys-87 prevents binding to phosphatidylinositol 3-phosphate (PI3P) and localization to early endosome membranes. ZFYVE28 is a negative regulator of epidermal growth factor receptor (EGFR) signaling. It acts by promoting EGFR degradation in endosomes when not mono-ubiquitinated. The FYVE domain has been identified in a number of unrelated signaling molecules. This protein functions to recruit SMAD2 to the transforming growth factor-beta receptor. The FYVE domain is required to maintain the normal localization of this protein but is not involved in mediating interaction with SMADs.
Optimal dilution of the ZFYVE28 antibody should be determined by the researcher.
A recombinant full-length human protein was used as the immunogen for this ZFYVE28 antibody.
Store the ZFYVE28 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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