Zebrafish Stat3 Antibody (RZ1195)

Description

Signal transducer and activator of transcription 3 (Stat3) is a key transcription factor involved in mediating cellular responses to cytokines and growth factors. In zebrafish (Danio rerio), Stat3 plays essential roles in early embryonic development, cell proliferation, inflammation, and tissue regeneration.

Activated through phosphorylation by Janus kinases (JAKs), Stat3 translocates to the nucleus, where it regulates target gene expression. In zebrafish, stat3 is dynamically expressed during embryogenesis and is required for processes such as gastrulation, organogenesis, and stem cell maintenance. It has been shown to be critical for liver and heart regeneration, as well as for innate immune responses to infection and injury.

Due to its high conservation and broad functional relevance, zebrafish Stat3 serves as a powerful model for studying JAK/STAT signaling, immune regulation, oncogenesis, and regenerative biology. It is also widely used in research on inflammatory diseases, developmental disorders, and signal transduction mechanisms in vertebrates.

Application Notes

Optimal dilution of the Zebrafish Stat3 antibody should be determined by the researcher.

Immunogen

E. coli-derived zebrafish Stat3 recombinant protein (amino acids K64-S335) was used as the immunogen for the Zebrafish Stat3 antibody.

Storage

After reconstitution, the Zebrafish Stat3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.