- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Zebrafish Ornithine aminotransferase Antibody / Oat (RZ1255)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RZ1255 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 539 |
| Availability | 2-3 weeks |
| Species Reactivity | Zebrafish |
| Format | Antigen affinity purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Purity | Antigen affinity chromatography |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | F8W5L3 |
| Localization | Cytoplasm |
| Applications | Immunohistochemistry (FFPE) : 2-5ug/ml |
| Limitations | This Zebrafish Ornithine aminotransferase antibody is available for research use only. |
|
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The Zebrafish Ornithine aminotransferase antibody targets Oat, a mitochondrial enzyme essential for amino acid metabolism, nitrogen balance, and retinal and hepatic function in Danio rerio. Zebrafish, also known as Danio rerio, express oat broadly during development, with strong enrichment in the liver, skeletal muscle, brain, and retina, reflecting its central role in metabolic homeostasis. Oat localizes to the mitochondrial matrix, where it catalyzes the reversible conversion of ornithine and alpha-ketoglutarate into glutamate semialdehyde and glutamate. This reaction supports the urea cycle, proline and polyamine synthesis, and metabolic pathways that manage nitrogen and carbon flow in developing tissues.
Oat belongs to the class I aminotransferase family, a group of pyridoxal phosphate-dependent enzymes involved in amino acid interconversion and mitochondrial metabolic regulation. In zebrafish embryos, oat expression increases as metabolic demands rise during organogenesis, particularly in tissues requiring active nitrogen recycling and mitochondrial energy production. A Zebrafish Ornithine aminotransferase antibody is suitable for detecting mitochondrial and cytoplasmic signals in metabolically active cells, aiding studies of nutrient metabolism, liver maturation, and retinal development.
Functionally, Oat plays major roles in maintaining nitrogen equilibrium and supporting metabolic networks that rely on glutamate and proline. In zebrafish, Oat-driven pathways sustain hepatic detoxification, mitochondrial redox balance, and amino acid interconversion. Oat is also essential for retinal health, as ornithine accumulation or impaired Oat function can disrupt photoreceptor metabolism and lead to retinal degeneration in vertebrates. During early development, Oat contributes to muscle differentiation, neurochemical balance, and metabolic adaptation as embryos transition from yolk-derived nutrients to external feeding. Because zebrafish are widely used to model metabolic disorders, Oat expression is a valuable indicator of mitochondrial activity and amino acid metabolism.
Structurally, zebrafish Oat contains conserved catalytic residues and a pyridoxal phosphate-binding domain typical of aminotransferases, enabling efficient amino group transfer. The protein is encoded by the oat gene on chromosome 23, with regulatory elements responsive to nutritional state, mitochondrial stress, and developmental cues. Co-localization studies frequently detect Oat within mitochondrial networks of hepatocytes, retinal cells, skeletal muscle fibers, and neurons, overlapping with markers of oxidative metabolism and nitrogen-processing enzymes.
A Zebrafish Ornithine aminotransferase antibody is suitable for detecting Oat in studies focused on amino acid metabolism, liver function, retinal development, mitochondrial biology, and nitrogen handling in Danio rerio. Its mitochondrial localization provides insight into metabolic bottlenecks, nutrient-dependent developmental shifts, and genetic disruptions affecting amino acid homeostasis. Oat expression is also used to examine metabolic disease models, retinal degeneration pathways, and physiological responses to altered nutrient availability or metabolic stress. These features make the antibody a valuable tool for research in developmental metabolism, mitochondrial function, and vertebrate biochemical regulation, and it is supplied for research use by NSJ Bioreagents.
Optimal dilution of the Zebrafish Ornithine aminotransferase antibody should be determined by the researcher.
E. coli-derived zebrafish Ornithine aminotransferase recombinant protein (amino acids A223-F444) was used as the immunogen for the Zebrafish Ornithine aminotransferase antibody.
After reconstitution, the Zebrafish Ornithine aminotransferase antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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