- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Zebrafish Mpeg1 Antibody / Mpeg1.1 / Macrophage-expressed gene 1 (RZ1240)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RZ1240 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 539 |
| Availability | 2-3 weeks |
| Species Reactivity | Zebrafish |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Purity | Antigen affinity chromatography |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | Q7SXE0 |
| Localization | Cytoplasm |
| Applications | Immunohistochemistry (FFPE) : 2-5ug/ml |
| Limitations | This Zebrafish Mpeg1 antibody is available for research use only. |
|
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The Zebrafish Mpeg1 antibody targets Mpeg1 (also known as Mpeg1.1), a macrophage-enriched membrane-associated protein essential for innate immunity, host defense, and myeloid lineage biology in Danio rerio. Zebrafish, also known as Danio rerio, express mpeg1.1 as a highly specific marker of macrophages beginning early in embryogenesis. Mpeg1 localizes to intracellular vesicles and membrane compartments within macrophages, where it contributes to antimicrobial activity and phagosomal maturation. Its expression provides a reliable readout of macrophage distribution, differentiation status, and immune activation across developmental stages.
Mpeg1 belongs to the perforin-like protein family, which contains membrane-attack complex/perforin (MACPF) domains involved in pore formation and antimicrobial defense. In zebrafish embryos and larvae, mpeg1.1 expression initiates in early myeloid populations arising from the rostral blood island and later becomes prominent in tissue-resident macrophages, including microglia. A Zebrafish Mpeg1 antibody is suitable for research applications examining cytoplasmic or vesicular labeling in macrophages, enabling precise visualization of myeloid lineage development and tissue-associated immune surveillance.
Functionally, Mpeg1 contributes to host defense by participating in macrophage-mediated microbial killing. Its MACPF domain is thought to support membrane-disruptive activity within phagosomes or on engulfed microbes. In zebrafish, mpeg1.1 expression marks macrophages that clear apoptotic cells, remodel tissues, and respond to infection or injury. Because mpeg1.1 is not expressed in neutrophils, it is widely used to distinguish macrophage-specific responses in studies of inflammation, wound healing, and innate immune activation. Mpeg1 also participates in immune modulation by influencing cytokine expression, phagocytic capacity, and macrophage maturation during early development.
Structurally, zebrafish Mpeg1 contains a signal peptide, a MACPF domain responsible for pore-forming activity, and C-terminal regions important for membrane association and vesicular trafficking. Zebrafish mpeg1.1 maps to chromosome 20, where promoter regions respond to key myeloid transcription factors such as pu.1/spi1b that drive macrophage lineage specification. Co-localization studies frequently detect Mpeg1 alongside macrophage markers including mpeg1.1-driven transgenics, lcp1, and csf1r, as well as microglial markers in neural tissues undergoing phagocytic remodeling.
A Zebrafish Mpeg1 antibody is suitable for detecting Mpeg1 in studies focused on macrophage biology, phagocytosis, inflammation, infection models, and innate immune system development in Danio rerio. Its strong specificity for macrophage-lineage cells allows researchers to track tissue-resident and migratory macrophages, evaluate immune responses to pathogens or injury, and characterize developmental or genetic phenotypes affecting myelopoiesis. Because zebrafish macrophages exhibit robust activity during embryonic development and regeneration, Mpeg1 expression provides a powerful marker for examining immune system dynamics, host defense mechanisms, and macrophage-mediated tissue interactions. This reagent is supplied for research use by NSJ Bioreagents.
Optimal dilution of the Zebrafish Mpeg1 antibody should be determined by the researcher.
E. coli-derived zebrafish Mpeg1 recombinant protein (amino acids Q68-S718) was used as the immunogen for the Zebrafish Mpeg1 antibody.
After reconstitution, the Zebrafish Mpeg1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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