Zebrafish Mmp9 Antibody / Matrix metalloproteinase 9 (RZ1239)

Description

Mmp9, or matrix metalloproteinase nine, is a zinc dependent endopeptidase that plays a central role in extracellular matrix remodeling during development, inflammation, and tissue repair. In zebrafish, Mmp9 is involved in multiple biological processes including fin regeneration, immune response, and neuronal development.

Mmp9 functions by degrading components of the extracellular matrix such as collagen and gelatin, allowing for tissue restructuring and cell migration. Its expression is tightly regulated and often induced by injury, infection, or developmental cues. In zebrafish, Mmp9 is notably upregulated in response to fin amputation and participates in the regeneration process by clearing damaged matrix and enabling cell proliferation.

In the immune system, zebrafish Mmp9 is expressed in neutrophils and macrophages and contributes to leukocyte recruitment and inflammation resolution. It is also involved in remodeling of the brain and other organs during development and in response to environmental stressors.

Due to its conservation across vertebrate species, zebrafish Mmp9 serves as a powerful model for studying matrix dynamics, regenerative biology, and inflammatory diseases. It is commonly used in genetic and chemical screens to explore pathways related to tissue remodeling and immune function.

Application Notes

Optimal dilution of the Zebrafish Mmp9 antibody should be determined by the researcher.

Immunogen

E. coli-derived zebrafish Mmp9 recombinant protein (amino acids D33-L680) was used as the immunogen for the Zebrafish Mmp9 antibody.

Storage

After reconstitution, the Zebrafish Mmp9 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.