- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Zebrafish IGF1 Receptor Antibody / IGF1RA Antibody recognizes Insulin-Like Growth Factor 1 Receptor Alpha (IGF1RA), a transmembrane receptor tyrosine kinase that mediates the biological effects of insulin-like growth factors and plays a central role in growth, development, metabolism, and cellular survival. IGF1RA is one of the zebrafish paralogs of the mammalian IGF1 receptor and functions through activation of intracellular signaling pathways including PI3K-AKT and MAPK cascades. Upon binding insulin-like growth factors, IGF1RA promotes cellular proliferation, differentiation, survival, and metabolic regulation. The highly conserved nature of IGF signaling has made zebrafish an important vertebrate model for investigating the developmental and physiological functions of this receptor.
IGF signaling is essential for normal embryonic growth and organ development. In zebrafish, IGF1RA contributes to regulation of body growth, skeletal formation, muscle development, nervous system maturation, and tissue homeostasis. Expression of IGF1RA is frequently examined in studies investigating developmental signaling pathways, endocrine regulation, and growth control mechanisms. Because the zebrafish embryo develops externally and remains optically transparent during early life stages, researchers can directly observe the consequences of altered IGF signaling during vertebrate development.
Beyond its developmental functions, IGF1RA plays a major role in regulating cellular metabolism and survival. Activation of the receptor promotes anabolic processes, supports cellular growth, and protects cells from apoptosis under physiological and stress-associated conditions. Dysregulation of IGF signaling pathways has been linked to developmental abnormalities, metabolic disorders, aging-related processes, and cancer-associated signaling mechanisms. Consequently, IGF1RA remains an important target in studies focused on growth factor signaling, regenerative biology, and disease pathogenesis.
Zebrafish models have become increasingly valuable for investigating IGF-dependent signaling because many of the molecular pathways governing growth and metabolism are highly conserved among vertebrates. Researchers frequently evaluate IGF1RA expression during studies of tissue regeneration, endocrine function, skeletal development, muscle biology, and environmental influences on growth regulation. Because IGF signaling interacts with numerous developmental and metabolic pathways, IGF1RA serves as a useful marker for examining cellular responses to physiological and experimental perturbations.
At NSJ Bioreagents, we provide highly validated antibodies for developmental biology, endocrinology, metabolism, and zebrafish research. Zebrafish IGF1 Receptor Antibody / IGF1RA Antibody targets a key receptor involved in growth factor signaling and cellular development. IGF1RA expression is widely studied in the context of growth regulation, tissue development, metabolism, regeneration, and intracellular signaling pathways. Continued investigation of this receptor is expanding our understanding of the molecular mechanisms that govern vertebrate growth, cellular homeostasis, and developmental physiology.
This Zebrafish antibody is part of a broader Zebrafish / Danio rerio antibody panel offered by NSJ Bioreagents.
The optimal working dilution of the Zebrafish IGF1 Receptor Antibody / IGF1RA Antibody should be determined empirically by the investigator.
An E.coli-derived Zebrafish IGF1RA recombinant protein (amino acids H36-R886) was used as the immunogen for the Zebrafish IGF1RA / IGF1 Receptor Antibody.
After reconstitution, the Zebrafish IGF1RA / IGF1 Receptor Antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Zebrafish IGF1RA Antibody, Zebrafish Insulin-Like Growth Factor 1 Receptor Alpha Antibody, Zebrafish IGF-1 Receptor Antibody, Zebrafish Insulin-Like Growth Factor Receptor Antibody, Zebrafish Growth Factor Receptor Antibody, Zebrafish IGF Signaling Receptor Antibody
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