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Home >> Antibodies >> Zebrafish Hras Antibody / Isoforms a & b

Zebrafish Hras Antibody / Isoforms a & b (RZ1080)

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Image RZ1080 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 539
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Immunohistochemical analysis of Hrasa/b protein using Zebrafish Hras antibody and paraffin-embedded zebrafish brain tissue. HIER: boil tissue sections in pH8 EDTA for 20 min and allow to cool before testing.
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Immunohistochemical analysis of Hrasa/b protein using Zebrafish Hras antibody and paraffin-embedded zebrafish brain tissue. HIER: boil tissue sections in pH8 EDTA for 20 min and allow to cool before testing.
Western blot analysis of Hrasa/b protein using Zebrafish Hras antibody and zebrafish head tissue lysate. The predicted molecular weight of Hrasa/b is 21 kDa.
Immunohistochemical analysis of Hrasa/b protein using Zebrafish Hras antibody and paraffin-embedded zebrafish cerebellum tissue. HIER: boil tissue sections in pH8 EDTA for 20 min and allow to cool before testing.
Immunohistochemical analysis of Hrasa/b protein using Zebrafish Hras antibody and paraffin-embedded zebrafish spinal cord tissue. HIER: boil tissue sections in pH8 EDTA for 20 min and allow to cool before testing.
Immunohistochemical analysis of Hrasa/b protein using Zebrafish Hras antibody and paraffin-embedded zebrafish eye tissue. HIER: boil tissue sections in pH8 EDTA for 20 min and allow to cool before testing.
Availability 2-3 weeks
Species Reactivity Zebrafish
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity chromatography
Buffer Lyophilized from 1X PBS with 2% Trehalose
UniProt Q568K0 , Q503B6
Localization Nuclear, cytoplasmic, cell membrane
Applications Western Blot : 0.5-1 ug/ml
Immunohistochemistry (FFPE) : 2-5 ug/ml
Limitations This Zebrafish Hras antibody is available for research use only.
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Description

GTPase HRas, also known as transforming protein p21, is an enzyme that in humans is encoded by the HRAS gene. This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.

Application Notes

Optimal dilution of the Zebrafish Hras antibody should be determined by the researcher.

Immunogen

An E.coli-derived zebrafish Hrasa/b recombinant protein (amino acids K101-S177) was used as the immunogen for the Zebrafish Hras antibody. This antibody will detect the a and b isoforms.

Storage

After reconstitution, the Zebrafish Hras antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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