- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Zebrafish Hnrnpd Antibody (RZ1021)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RZ1021 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 539 |
| Availability | 2-3 weeks |
| Species Reactivity | Zebrafish |
| Format | Antigen affinity purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Purity | Antigen affinity chromatography |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | A0A8M9QC46 |
| Localization | Cytoplasm, Nucleus |
| Applications | Western Blot : 0.5-1 ug/ml Immunohistochemistry (FFPE) : 2-5 ug/ml Immunofluorescence : 5 ug/ml |
| Limitations | This Zebrafish Hnrnpd antibody is available for research use only. |
|
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Zebrafish (Danio rerio) Hnrnpd antibody recognizes heterogeneous nuclear ribonucleoprotein D, a conserved RNA binding protein encoded by the zebrafish hnrnpd gene on chromosome 9. Hnrnpd belongs to the hnRNP family of RNA regulatory proteins that govern mRNA stability, processing, transport, and translational control. Also known as AU rich element binding protein 1, Hnrnpd binds sequences in the 3 prime untranslated regions of target transcripts to modulate their degradation rates and expression levels. In Danio rerio, Hnrnpd is expressed during early embryogenesis and is enriched in neural progenitors, somites, hematopoietic precursors, and early endodermal tissues where rapid transcript turnover supports developmental gene expression programs. Subcellular localization includes the nucleus, cytoplasm, stress granules, and processing bodies, reflecting its role in dynamic RNA regulation.
Heterogeneous nuclear ribonucleoprotein D plays a central role in controlling mRNA decay by binding AU rich elements within unstable transcripts involved in differentiation, inflammation, and cell cycle control. In zebrafish embryos, Hnrnpd regulates the timing and amplitude of gene expression programs required for morphogenesis, tissue patterning, and neural development. By influencing transcript stability, Hnrnpd helps coordinate cell fate transitions and ensures proper progression through developmental milestones. Hnrnpd also contributes to alternative splicing, mRNA export, and translational regulation, placing it at the intersection of several post transcriptional pathways.
Developmental studies indicate that Hnrnpd function is essential for processes dependent on rapid RNA remodeling. In neural tissues, Hnrnpd influences the stability of transcripts involved in axon growth, synaptic development, and neuronal differentiation. In somites and muscle precursors, it regulates RNA turnover required for myogenic progression and metabolic adaptation. Hnrnpd also contributes to hematopoiesis by controlling inflammatory and cytokine-response transcripts that shape early immune cell development. Because zebrafish embryos rely on finely tuned mRNA decay to manage rapid developmental transitions, Hnrnpd is a key regulator of transcriptome flexibility.
Hnrnpd participates in stress response pathways that influence RNA granule formation, mRNA triage, and translational suppression. Under environmental or metabolic stress, Hnrnpd redistributes to stress granules where it protects, stores, or represses selected transcripts. These processes support developmental resilience and allow embryonic tissues to adjust to fluctuations in nutrient availability, temperature, or chemical exposure. Dysregulation of Hnrnpd or related hnRNPs can lead to defects in neural patterning, impaired tissue growth, and aberrant inflammatory responses in vertebrate systems.
At the molecular level, heterogeneous nuclear ribonucleoprotein D contains multiple RNA binding domains and intrinsically disordered regions that support flexible interactions with RNA and protein partners. Hnrnpd influences mRNA decay through competition with stabilizing proteins, recruitment of deadenylation machinery, and modulation of transcript access to decay complexes. Isoform variation may arise through alternative splicing and could reflect tissue-specific regulatory roles during zebrafish development. Hnrnpd interfaces with signaling pathways such as FGF, Wnt, and cytokine networks by shaping the post transcriptional fate of their downstream transcripts.
This Zebrafish Hnrnpd antibody is suitable for detecting heterogeneous nuclear ribonucleoprotein D in research focused on RNA stability, AU rich element mediated decay, neural development, stress granule biology, and embryonic patterning in zebrafish. It supports studies examining post transcriptional regulation, RNA-binding protein interactions, and developmental phenotypes arising from disrupted mRNA turnover. NSJ Bioreagents provides this reagent within its zebrafish and RNA biology antibody collection.
Optimal dilution of the Zebrafish Hnrnpd antibody should be determined by the researcher.
An E.coli-derived zebrafish Hnrnpd recombinant protein (amino acids K43-N203) was used as the immunogen for the Zebrafish Hnrnpd antibody.
After reconstitution, the Zebrafish Hnrnpd antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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